Imaging flow cytometry: from high - resolution morphological imaging to innovation in high - throughput multidimensional biomedical analysis.

Journal: Frontiers in bioengineering and biotechnology
Published Date: Jan 1, 2025

Abstract

Imaging flow cytometry (IFC), as an extension of conventional flow cytometry, has emerged as a cutting-edge cellular analysis tool by integrating high-resolution imaging technology, and has shown significant potential and application value in biomedical research. In this paper, we comprehensively review the evolution of IFC from its early theoretical development to its current mature application, and explain its working principle, unique advantages, and the current status of its application in several biomedical fields. The paper focuses on how IFC integrates high-throughput and morphological imaging, highlighting its key role in cell biology, immunology, oncology, and environmental monitoring. Furthermore, the paper addresses the challenges and opportunities in data analysis, and proposes the potential of artificial intelligence (AI) and machine learning technologies to drive its progress. The paper concludes with an outlook on the future of IFC, predicting its application in emerging research areas and emphasizing the role of continuous technological innovation in driving the development of the field. It aims to provide researchers with a comprehensive view of IFC to promote its widespread application in biomedical research.

Authors

  • Qing Huang
    Department of Environmental Health and Occupational Medicine,West China School of Public Health,Sichuan University,Chengdu 610041,China.
  • Zhengyu Zhou
    Department of Laboratory Diagnostics, Changhai Hospital, Naval Medical University, Shanghai, China.
  • Qiao Lv
    Clinical Medical Research Center, Xinqiao Hospital, Army Medical University, Chongqing, China.
  • Qian Min
    School of Science, China Pharmaceutical University, Nanjing, China.
  • Lu Jiang
    Institute of Materials Research and Engineering (IMRE), A*STAR, 2 Fusionopolis Way, #08-03 Innovis, Singapore 138634.
  • Qian Chen
    Department of Pain Medicine Guizhou Provincial Orthopedics Hospital Guiyang Guizhou China.
  • Jin Peng
    Institute for Emergency and Disaster Medicine, Sichuan Academy of Medical Sciences, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, No. 32, Yi Huan Lu Xi Er Duan, Chengdu, Sichuan Province, China; Sino-Finnish Medical AI Research Center, No. 32, Yi Huan Lu Xi Er Duan, Chengdu, Sichuan Province, China; Department of Histology, Embryology and Neurobiology, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, No. 17, People's South Road, Chengdu, Sichuan, China. Electronic address: admin@traumabank.org.
  • Hongli Zhou
    Clinical Medical Research Center, Xinqiao Hospital, Army Medical University, Chongqing, China.
  • Ju Zhou
    Department of Bone and Joint Surgery, Affiliated Hospital of Southwest Medical University, Luzhou Sichuan, 646000, P.R.China.
  • Qian Dai
    School of Foreign Languages, Henan Polytechnic University, Jiaozuo 454003, Henan Province, China.
  • Jianyun Zhou
    Clinical Medical Research Center, Xinqiao Hospital, Army Medical University, Chongqing, China.

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