Circulating Antioxidant Nutrients and Brain Age in Midlife Adults.

Journal: Biopsychosocial science and medicine
Published Date: May 9, 2025

Abstract

OBJECTIVE: Due to population aging, the increasing prevalence of Alzheimer's Disease (AD) and related dementias are major public health concerns. Dietary consumption of antioxidant nutrients, in particular the carotenoid β-carotene, has been associated with lower age-related neurocognitive decline. What is unclear, however, is the extent to which antioxidant nutrients may exert neuroprotective effects via their influence on established indicators of age-related changes in brain tissue. This study thus tested associations of circulating β-carotene and other nutrients with a structural neuroimaging indicator of brain age derived from cross-validated machine learning models trained to predict chronological age from brain tissue morphology in independent cohorts.

Authors

  • Mason J Lower
    Department of Neuroscience, University of Pittsburgh, A210 Langley Hall Langley Hall, Pittsburgh, PA 15260, United States (Lower); Department of Psychology, University of Pittsburgh, Sennott Square 3417, 210 S. Bouquet Street, Pittsburgh, PA 15260, United States (DeCataldo, Gianaros); Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15260, United States (Kraynak).
  • Mia K DeCataldo
  • Thomas E Kraynak
  • Peter J Gianaros
    Department of Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.

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