Association of RDoC dimensions with brain transcriptional profiles in Alzheimer's disease.

Journal: Alzheimer's & dementia (Amsterdam, Netherlands)
Published Date: Jan 1, 2025

Abstract

INTRODUCTION: Neuropsychiatric symptoms are common in people with Alzheimer's disease (AD) across all severity stages. Their heterogeneous presentation and variable temporal association with cognitive decline suggest shared and distinct biological mechanisms. We hypothesized that specific patterns of gene expression associate with distinct National Institute of Mental Health Research Domain Criteria (RDoC) domains in AD.

Authors

  • Weiqian Jiang
    Department of Psychiatry Harvard Medical School McLean Hospital Belmont Massachusetts USA.
  • Jonathan Vogelgsang
    Department of Psychiatry Harvard Medical School McLean Hospital Belmont Massachusetts USA.
  • Shu Dan
    Department of Psychiatry Harvard Medical School McLean Hospital Belmont Massachusetts USA.
  • Peter Durning
    Department of Psychiatry Harvard Medical School McLean Hospital Belmont Massachusetts USA.
  • Thomas H McCoy
    Center for Quantitative Health, Department of Psychiatry and Department of Medicine, Massachusetts General Hospital, Boston, MA. Electronic address: thmccoy@partners.org.
  • Sabina Berretta
    Department of Psychiatry Harvard Medical School McLean Hospital Belmont Massachusetts USA.
  • Torsten Klengel
    Department of Psychiatry Harvard Medical School McLean Hospital Belmont Massachusetts USA.

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