Beyond beauty: Neurocosmetics, the skin-brain axis, and the future of emotionally intelligent skincare.

Journal: Clinics in dermatology
Published Date: May 10, 2025

Abstract

The bidirectional communication between the skin and brain has emerged as a promising scientific paradigm in dermatology and cosmetic medicine. Neurocosmetics, a frontier at the intersection of neuroscience, dermatology, and psychodermatology, aims to target this skin-brain axis to enhance not only skin health but also emotional well being. This commentary explores the underlying neurocutaneous and neuroimmune mechanisms, the emerging role of the skin microbiome in emotion-linked skin responses, and how artificial intelligence technologies can help personalize these strategies. The convergence of neuroscience and dermatology may pave the way for a new generation of evidence-based skincare with psychophysiological impact, a transformative concept in clinical and cosmetic practice.

Authors

  • Diala Haykal
    Centre Laser Palaiseau, Private Practice, Palaiseau, France.
  • Enzo Berardesca
    Phillip Frost Department of Dermatology, University of Miami Miller School of Medicine, Miami, FL, USA.
  • Kenji Kabashima
    Department of Dermatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan; Singapore Immunology Network (SIgN) and Institute of Medical Biology (IMB), Agency for Science, Technology and Research (A*STAR), Biopolis, Singapore.
  • Brigitte Dréno
    Department of Dermatology, Nantes University Hospital, Nantes, France.

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