Changes in serum concentration of perioperative inflammatory cytokines following the timing of surgery among mild-moderate traumatic brain injury patients and factors associated.

Journal: Frontiers in neurology
Published Date: Dec 18, 2024

Abstract

BACKGROUND: The safe timing window for surgery during the acute phase of inflammation due to traumatic brain injury (TBI) has not been studied extensively. We aimed to elucidate the relationship between the timing of surgery and changes in perioperative serum levels of inflammatory cytokines and factors associated to optimize TBI management in low-middle-income countries.

Authors

  • HervĂ© Monka Lekuya
    Department of Surgery, College of Health Sciences, Makerere University, Kampala, Uganda.
  • Stephen Cose
    Medical Research Council, London School of Hygiene and Tropical Medicine, Immunology, Entebbe, Uganda.
  • Marjorie Nakibuule
    Medical Research Council, London School of Hygiene and Tropical Medicine, Immunology, Entebbe, Uganda.
  • Gift Ahimbisibwe
    Medical Research Council, London School of Hygiene and Tropical Medicine, Immunology, Entebbe, Uganda.
  • Anthony Fuller
    Duke Global Neurology and Neurosurgery, Duke University, Durham, NC, United States.
  • Larrey Kasereka Kamabu
    Department of Human Repair, Neurosurgery, Ghent University, Ghent, Belgium.
  • Emmanuel Biryabarema
    Department of Molecular Biology, College of Health Sciences, Makerere University, Kampala, Uganda.
  • Geoffrey Olweny
    Department of Molecular Biology, College of Health Sciences, Makerere University, Kampala, Uganda.
  • David Patrick Kateete
    Department of Molecular Biology, College of Health Sciences, Makerere University, Kampala, Uganda.
  • Anthony Kirabira
    School of Public Health, College of Health Sciences, Makerere University, Kampala, Uganda.
  • Fredrick Makumbi
    School of Public Health, College of Health Sciences, Makerere University, Kampala, Uganda.
  • Jelle Vandersteene
    Department of Human Repair, Neurosurgery, Ghent University, Ghent, Belgium.
  • Edward Baert
    Department of Human Repair, Neurosurgery, Ghent University, Ghent, Belgium.
  • Moses Galukande
    Department of Surgery, College of Health Sciences, Makerere University, Kampala, Uganda.
  • Jean-Pierre Okito Kalala
    Department of Human Repair, Neurosurgery, Ghent University, Ghent, Belgium.

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