Manual Delineation of the Region of Interest Combined With Clinical Image Analysis to Predict the Ki-67 Expression Level in Non-small Cell Lung Cancer.

Journal: Sage open pathology
Published Date: Jan 1, 2025

Abstract

BACKGROUND: The Ki-67 antigen, a marker of cell proliferation, serves as a biomarker for assessing tumor malignancy. However, measuring Ki-67 levels through immunohistochemistry is often challenging due to difficulties in specimen collection and individual health issues. Radiological analysis has emerged as a potential alternative for predicting Ki-67 levels, although its accuracy has been limited. This study aims to enhance the prediction of Ki-67 levels using chest X-rays by employing a refined approach that combines detailed, manually delineated radiological features with conventional imaging characteristics.

Authors

  • Yizhi Li
    Department of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, 410000, China.
  • Jia Zhang
    Department of Geriatrics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.
  • Xiaodan Lin
    Department of Radiation Therapy, Affillated Cancer Hospital and Institute of Guangzhou Medical University, Guangzhou Medical University, China.

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