Identification of novel potential hypoxia-inducible factor-1α inhibitors through machine learning and computational simulations.

Journal: Frontiers in chemistry
Published Date: Jan 1, 2025

Abstract

INTRODUCTION: Hypoxia-inducible factor-1α (HIF-1α) has become a significant therapeutic target for breast cancer and other cancers by regulating the expression of downstream genes such as erythropoietin, thereby improving cell survival in hypoxic conditions.

Authors

  • Yuxiang He
    Department of Vascular Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.
  • Shuning Diao
    First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, China.
  • Shengzhen Hou
    First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, China.
  • Taiying Li
    First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, China.
  • Wenhui Meng
    Third Department of Infectious Diseases, The Fourth People's Hospital of Zibo, Zibo, China.
  • Jinping Zhang
    Department of Endocrinology, China-Japan Friendship Hospital, Beijing, China.

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