Single-cell transcriptomics and machine learning unveil ferroptosis features in tumor-associated macrophages: Prognostic model and therapeutic strategies for lung adenocarcinoma.

Journal: Frontiers in pharmacology
Published Date: Jan 1, 2025

Abstract

BACKGROUND: Lung adenocarcinoma (LUAD) is a major cause of cancer-related mortality worldwide. Tumor-associated macrophages (TAMs) play a crucial role in the tumor microenvironment (TME), influencing tumor progression and immune response. Ferroptosis, an iron-dependent form of regulated cell death, has been implicated in tumor biology, but its role within TAMs in LUAD remains unclear.

Authors

  • Ting Ji
    Department of Key Laboratory of Ningxia Stem Cell and Regenerative Medicine, Institute of Medical Sciences, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, China.
  • Juanli Jiang
    Department of Neurology, The First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan, China.
  • Xin Wang
    Key Laboratory of Bio-based Material Science & Technology (Northeast Forestry University), Ministry of Education, Harbin 150040, China.
  • Kai Yang
    Department of Radiology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
  • Shaojin Wang
    School of Northwest A & F University, Yangling, Shaanxi 712100, China.
  • Bin Pan
    Department of Emergency Intensive Care Unit, Changshu Hospital Affiliated to Soochow University, Changshu, China.

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