BrainVAE: Exploring the role of white matter BOLD in preclinical Alzheimer's disease classification.

Journal: bioRxiv : the preprint server for biology
Published Date: May 13, 2025

Abstract

INTRODUCTION: Like gray matter (GM), white matter (WM) BOLD functional signals change in preclinical AD. However, the potential of WM BOLD for identifying preclinical AD remains underexplored.

Authors

  • Yikang Li
    Vanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, United States.
  • Lyuan Xu
    Vanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, United States.
  • Lianrui Zuo
    Dept. of Electrical and Computer Engineering, The Johns Hopkins University, Baltimore, MD 21218, USA; Laboratory of Behavioral Neuroscience, National Institute on Aging, National Institute of Health, Baltimore, MD 20892, USA.
  • Yukie Chang
    Department of Computer Science, Pomona College, Claremont, CA, United States.
  • Zhaohua Ding
    Vanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, United States.
  • Adam W Anderson
    Vanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Kurt G Schilling
    Vanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, USA.
  • John C Gore
    Vanderbilt University Institute of Imaging Science, USA. Electronic address: john.gore@vanderbilt.edu.
  • Yurui Gao
    Vanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, USA.

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