Deep Learning-Derived Cardiac Chamber Volumes and Mass From PET/CT Attenuation Scans: Associations With Myocardial Flow Reserve and Heart Failure.

Journal: Circulation. Cardiovascular imaging
Published Date: May 13, 2025

Abstract

BACKGROUND: Computed tomography (CT) attenuation correction scans are an intrinsic part of positron emission tomography (PET) myocardial perfusion imaging using PET/CT, but anatomic information is rarely derived from these ultralow-dose CT scans. We aimed to assess the association between deep learning-derived cardiac chamber volumes (right atrial, right ventricular, left ventricular, and left atrial) and mass (left ventricular) from these scans with myocardial flow reserve and heart failure hospitalization.

Authors

  • Waseem Hijazi
    Department of Cardiac Sciences, University of Calgary, GAA08, 3230 Hospital Drive NW, Calgary, AB, T2N 2T9, Canada.
  • Aakash Shanbhag
    Division of Artificial Intelligence, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
  • Robert J H Miller
    Department of Imaging and Medicine and the Smidt Heart Institute (E.E., S.C., H.G., S.C., R.J.H.M., P.J.S., B.K.T., D.S.B.), Cedars-Sinai Medical Center, Los Angeles, CA.
  • Paul B Kavanagh
    Departments of Medicine (Division of Artificial Intelligence in Medicine), Biomedical Sciences and Imaging, Cedars-Sinai Medical Center, Los Angeles, California, USA.
  • Aditya Killekar
    Division of Artificial Intelligence, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
  • Mark Lemley
    Oregon Heart and Vascular Institute, Sacred Heart Medical Center, Springfield, Oregon.
  • Samuel Wopperer
    Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN (S.W., P.C.).
  • Stacey Knight
    Department of Medicine, University of Utah, Salt Lake City (S.K., V.T.L., S.M.).
  • Viet T Le
    Cardiovascular Department, Intermountain Medical Center Heart Institute, Salt Lake City, UT, United States.
  • Steve Mason
    Department of Medicine, University of Utah, Salt Lake City (S.K., V.T.L., S.M.).
  • Wanda Acampa
    Institute of Biostructure and Bioimaging, National Council of Research, Naples, Italy.
  • Tom Rosamond
    Nuclear Cardiology Department, Kansas University Medical Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA. (T.R.).
  • Damini Dey
    Departments of Imaging and Medicine, and Cedars-Sinai Heart Institute, Cedars-Sinai Medical Center, 8700 Beverly Blvd, Taper A238, Los Angeles, CA, 90048, USA.
  • Daniel S Berman
    Departments of Imaging and Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
  • Panithaya Chareonthaitawee
    Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN.
  • Marcelo F Di Carli
    Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
  • Piotr J Slomka
    Department of Imaging, Medicine, and Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California Piotr.Slomka@cshs.org.

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