Intermuscular adipose tissue and lean muscle mass assessed with MRI in people with chronic back pain in Germany: a retrospective observational study.

Journal: The Lancet regional health. Europe
Published Date:

Abstract

BACKGROUND: Chronic back pain (CBP) affects over 80 million people in Europe, contributing to substantial healthcare costs and disability. Understanding modifiable risk factors, such as muscle composition, may aid in prevention and treatment. This study investigates the association between lean muscle mass (LMM) and intermuscular adipose tissue (InterMAT) with CBP using noninvasive whole-body magnetic resonance imaging (MRI).

Authors

  • Sebastian Ziegelmayer
    Department of Diagnostic and Interventional Radiology, School of Medicine, Technical University of Munich, Munich, Germany.
  • Hartmut Häntze
    Department of Radiology, Charite - Universitatsmedizin Berlin, Berlin, Germany.
  • Christian Mertens
    Department of Diagnostic and Interventional Radiology, Technical University of Munich, School of Medicine and Health, Klinikum Rechts der Isar, TUM University Hospital, Ismaninger Str. 22, 81675, Munich, Germany.
  • Felix Busch
    Institute for Diagnostic and Interventional Radiology, TUM School of Medicine and Health, TUM University Hospital Rechts der Isar, Technical University of Munich, Munich, Germany.
  • Tristan Lemke
    Institute of Diagnostic and Interventional Radiology, Technical University of Munich, School of Medicine, Munich, Germany.
  • Jakob Nikolas Kather
    Department of Medicine III, University Hospital RWTH Aachen, Aachen, Germany.
  • Daniel Truhn
    Department of Diagnostic and Interventional Radiology, University Hospital Düsseldorf, Düsseldorf, Germany (J.S., D.B.A., S.N.); Institute of Computer Vision and Imaging, RWTH University Aachen, Pauwelsstrasse 30, 52072 Aachen, Germany (J.S., D.M.); Department of Diagnostic and Interventional Radiology, University Hospital Aachen, Aachen, Germany (D.T., M.P., F.M., C.K., S.N.); and Faculty of Mathematics and Natural Sciences, Institute of Informatics, Heinrich Heine University Düsseldorf, Düsseldorf, Germany (S.C.).
  • Su Hwan Kim
    Department of Internal Medicine, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul, Republic of Korea.
  • Benedikt Wiestler
    Department of Neuroradiology, Klinikum rechts der Isar, Technical University of Munich (TUM), Ismaninger Straße 22, 81675 Munich, Germany; Deutsches Konsortium für Translationale Krebsforschung (DKTK), Partner Site Munich, Germany.
  • Markus Gräf
    Department of Internal Medicine 3, Friedrich-Alexander-University Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany.
  • Avan Kader
    Department of Diagnostic and Interventional Radiology, Technical University of Munich, School of Medicine and Health, Klinikum Rechts der Isar, TUM University Hospital, Ismaninger Str. 22, 81675, Munich, Germany.
  • Fabian Bamberg
    Department of Diagnostic and Interventional Radiology, University Medical Center Tübingen, Tübingen, Germany.
  • Christopher L Schlett
    From the MTA-SE Cardiovascular Imaging Research Group, Heart and Vascular Center, Semmelweis University, 68 Varosmajor St, 1122 Budapest, Hungary (M.K., J.K., B.M., P.M.H.); Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Mass (J.K., Y.K., A.I., M.T.L., B.F., H.J.A., U.H.); Center for Cause of Death Investigation, Faculty of Medicine, Hokkaido University, Hokkaido, Japan (Y.K.); Department for Diagnostic and Interventional Radiology, Medical Center-University of Freiburg, Freiburg, Germany (C.L.S.); and Department of Radiation Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass (H.J.A.).
  • Jakob B Weiss
    Department of Diagnostic and Interventional Radiology, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
  • Jeanette Schulz-Menger
    Charité-Universitätsmedizin Berlin, Experimental and Clinical Research Center, Working Group On CMR and HELIOS Klinikum Berlin Buch, Cardiology Berlin, DZHK partnersite Berlin, Berlin, Germany.
  • Steffen Ringhof
    Department of Radiology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany.
  • Elif Can
    Department of Radiology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany.
  • Tobias Pischon
    Max-Delbrueck-Center for Molecular Medicine in the Helmholtz Association (MDC), Molecular Epidemiology Research Group, Berlin, Germany.
  • Thoralf Niendorf
    Berlin Ultrahigh Field Facility, Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.
  • Jacqueline Lammert
    Department of Gynecology and Center for Hereditary Breast and Ovarian Cancer, Technical University of Munich (TUM), School of Medicine and Health, Klinikum Rechts der Isar, TUM University Hospital, Munich, Germany.
  • Matthias Schulze
    Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.
  • Thomas Keil
    Institute of Social Medicine, Epidemiology and Health Economics, Charité-Universitätsmedizin Berlin, Berlin, Germany.
  • Annette Peters
    Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
  • Martin Hadamitzky
    School of Medicine and Health, Institute for Cardiovascular Radiology and Nuclear Medicine, German Heart Center Munich, TUM University Hospital, Technical University of Munich, Munich, Germany.
  • Marcus R Makowski
    School of Medicine and Health, Department of Diagnostic and Interventional Radiology, Klinikum rechts der Isar, TUM University Hospital, Technical University of Munich, Munich, Germany.
  • Lisa Adams
    Department of Radiology, Charité - Universitätsmedizin Berlin, Hindenburgdamm 30, 12203, Berlin, Germany.
  • Keno Bressem
    Department of Radiology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, 10117 Berlin, Germany.

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