Gray and white matter alterations in Obsessive-Compulsive Personality Disorder: a data fusion machine learning approach.

Journal: Frontiers in human neuroscience
Published Date: Jan 1, 2025

Abstract

INTRODUCTION: Obsessive-Compulsive Personality Disorder (OCPD) is a complex mental condition marked by excessive perfectionism, orderliness, and rigidity, often starting in adolescence or early adulthood; it affects 1.9% to 7.8% of the population. The disorder differs from Obsessive-Compulsive Disorder (OCD) in an apparent compromise of personality, distorted self-representation, and altered perception of others. Although the two disorders present evident differences, unlike OCD, the neural bases of OCPD are understudied. The few studies conducted so far have identified gray matter alterations in brain regions such as the striatum and prefrontal cortex. However, a comprehensive model of its neurobiology and the eventual contribution of white matter abnormalities are still unclear. One intriguing hypothesis is that regions ascribed to the Default Mode Network are involved in OCPD, similar to what has been shown for OCD and other anxiety disorders.

Authors

  • Lorenzo Arena
    Department of Psychology and Cognitive Science, University of Trento, Trento, Italy.
  • Wenceslao Peñate
    Departamento de Psicología Clínica, Psicobiología y Metodología, Facultad de Psicología, Universidad de La Laguna, La Laguna, Tenerife, Spain.
  • Francisco Rivero
    Departamento de Psicología, Facultad de Ciencias de la Salud, Universidad Europea de Canarias, La Orotava, Tenerife, Spain.
  • Rosario J Marrero
    Departamento de Psicología Clínica, Psicobiología y Metodología, Facultad de Psicología, Universidad de La Laguna, La Laguna, Tenerife, Spain.
  • Teresa Olivares
    Departamento de Psicología Clínica, Psicobiología y Metodología, Facultad de Psicología, Universidad de La Laguna, La Laguna, Tenerife, Spain.
  • Alessandro Scarano
    Department of Psychology and Cognitive Science, University of Trento, Trento, Italy.
  • Ascensión Fumero
    Departamento de Psicología Clínica, Psicobiología y Metodología, Facultad de Psicología, Universidad de La Laguna, La Laguna, Tenerife, Spain.
  • Alessandro Grecucci
    Clinical and Affective Neuroscience Lab, Department of Psychology and Cognitive Sciences (DiPSCo), University of Trento, Rovereto, Italy.

Keywords

No keywords available for this article.

External Resources

Popular Topics
Recent Journals