Identification and validation of pyroptosis-related genes in Alzheimer's disease based on multi-transcriptome and machine learning.

Journal: Frontiers in aging neuroscience
Published Date: Jan 1, 2025

Abstract

BACKGROUND: Alzheimer's disease (AD) progression is characterized by persistent neuroinflammation, where pyroptosis-an inflammatory programmed cell death mechanism-has emerged as a key pathological contributor. However, the molecular mechanisms through which pyroptosis-related genes (PRGs) drive AD pathogenesis remain incompletely elucidated.

Authors

  • Yuntai Wang
    Institute of Basic Medicine, North Sichuan Medical College, Nanchong, China.
  • Yilin Li
    Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Gastrointestinal Oncology, Peking University Cancer Hospital & Institute, Beijing 100142, China.
  • Lu Zhou
    School of Environment, Tsinghua University Beijing 100084 P. R. China zhoulu@mail.tsinghua.edu.cn.
  • Yihuan Yuan
    School of Clinical Medicine, North Sichuan Medical College, Nanchong, China.
  • Chuanfei Liu
    School of Medical Imaging, North Sichuan Medical College, Nanchong, China.
  • Zimeng Zeng
    Institute of Basic Medicine, North Sichuan Medical College, Nanchong, China.
  • Yuanqi Chen
    School of Nursing, North Sichuan Medical College, Nanchong, China.
  • Qi He
    Key Laboratory of Mechanism Theory and Equipment Design of Ministry of Education, Tianjin University, Tianjin, China.
  • Zhuoze Wu
    Institute of Basic Medicine, North Sichuan Medical College, Nanchong, China.

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