Generative Deep Learning Design of Single-Domain Antibodies Against Venezuelan Equine Encephalitis Virus.

Journal: Antibodies (Basel, Switzerland)
Published Date: May 14, 2025

Abstract

BACKGROUND/OBJECTIVES: Venezuelan equine encephalitis virus (VEEV) represents a significant biothreat with no FDA-approved vaccine currently available, highlighting the need for alternative therapeutic strategies. Single-domain antibodies (sdAbs) present a potential alternative to conventional antibodies, due to their small size and ability to recognize cryptic epitopes.

Authors

  • Jinny L Liu
    Center for Bio/Molecular Science and Engineering, US Naval Research Laboratory, Washington, DC 20375, USA.
  • Gabrielle C Bayacal
    Naval Research Enterprise Internship Program, US Naval Research Laboratory, Washington, DC 20375, USA.
  • Jerome Anthony E Alvarez
    Center for Bio/Molecular Science and Engineering, US Naval Research Laboratory, Washington, DC 20375, USA.
  • Lisa C Shriver-Lake
    Center for Bio/Molecular Science and Engineering, US Naval Research Laboratory, Washington, DC 20375, USA.
  • Ellen R Goldman
    Center for Bio/Molecular Science and Engineering, US Naval Research Laboratory, Washington, DC 20375, USA.
  • Scott N Dean
    Center for Bio/Molecular Science and Engineering, US Naval Research Laboratory, Washington, DC 20375, USA.

Keywords

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