Simplifying Diagnosis of Bile Acid Diarrhea With Clinical and Biochemical Measurements on Blood and Single Stool Sample.

Journal: Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
Published Date: May 14, 2025

Abstract

BACKGROUND AND AIMS: Diagnosis of bile acid diarrhea (BAD) has been based on 48-hour fecal BA excretion; serum 7αC4 (C4) has been used to screen for BAD. Optimal diagnostic cutoffs for C4 and biochemical measurements in a single stool sample are unknown. We sought to examine the relationship between total BA concentration (TBAc) and percent primary BA (%PBA) in a single stool sample and serum C4 in patients with and without BAD and explore performance characteristics of stool consistency and biochemical (serum C4 and single-stool BA) parameters for diagnosis of BAD compared with gold standard 48-hour fecal BA.

Authors

  • Saam Dilmaghani
    Clinical Enteric Neuroscience Translational and Epidemiological Research, Mayo Clinic, Rochester, Minnesota.
  • Camille Lupianez-Merly
    Clinical Enteric Neuroscience Translational and Epidemiological Research, Mayo Clinic, Rochester, Minnesota.
  • Joelle BouSaba
    Clinical Enteric Neuroscience Translational and Epidemiological Research, Mayo Clinic, Rochester, Minnesota.
  • Priya Vijayvargiya
    Clinical Enteric Neuroscience Translational and Epidemiological Research, Mayo Clinic, Rochester, Minnesota.
  • Irene Busciglio
    Clinical Enteric Neuroscience Translational and Epidemiological Research, Mayo Clinic, Rochester, Minnesota.
  • Monique Ferber
    Clinical Enteric Neuroscience Translational and Epidemiological Research, Mayo Clinic, Rochester, Minnesota.
  • Paula Carlson
    Clinical Enteric Neuroscience Translational and Epidemiological Research, Mayo Clinic, Rochester, Minnesota.
  • Leslie J Donato
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota.
  • Michael Camilleri
    Clinical Enteric Neuroscience Translational and Epidemiological Research, Mayo Clinic, Rochester, Minnesota. Electronic address: camilleri.michael@mayo.edu.

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