The gut microbiome and metabolome in children with a first febrile urinary tract infection: a pilot study.

Journal: Pediatric nephrology (Berlin, Germany)
Published Date: May 14, 2025

Abstract

BACKGROUND: Urinary tract infection (UTI) is a common bacterial infection in the pediatric population. Febrile urinary tract infection (fUTI) can lead to severe complications such as urosepsis as well as kidney scarring, chronic kidney disease, and systemic hypertension. Recent research supports the hypothesis that dysbiosis of the microbiome may play a role in the pathogenesis and development of fUTI in infants. Our main aim was to compare the shift in gut microbiota composition between children with the first fUTI and controls.

Authors

  • Barbora Piteková
    Department of Pediatric Emergency Medicine, National Institute of Children's Diseases, Bratislava, Slovakia.
  • Ivan Hric
    Biomedical Center, Institute of Clinical and Translational Research, Slovak Academy of Sciences, Bratislava, Slovakia.
  • Jakub Zieg
    Department of Pediatrics, Second Faculty of Medicine, Charles University, Prague, Czech Republic.
  • Eva Baranovičová
    Biomedical Center Martin, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovakia.
  • Patrik Konopásek
    Department of Children and Adolescents, Third Faculty of Medicine, Charles University and University Hospital Kralovske Vinohrady, Prague, Czech Republic.
  • Jakub Gécz
    Department of Pediatric Emergency Medicine, National Institute of Children's Diseases, Bratislava, Slovakia.
  • Paul J Planet
    Children's Hospital of Philadelphia, Philadelphia, PA, USA.
  • Viktor Bielik
    Department of Biological and Medical Sciences, Faculty of Physical Education and Sport, Comenius University, Bratislava, Slovakia. viktor.bielik@uniba.sk.

Keywords

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