Detection of Hypertrophic Cardiomyopathy on Electrocardiogram Using Artificial Intelligence.

Journal: Circulation. Heart failure
Published Date:

Abstract

BACKGROUND: Hypertrophic cardiomyopathy (HCM) is associated with significant morbidity and mortality, including sudden cardiac death in the young. Its prevalence is estimated to be 1 in 500, although many people are undiagnosed. The ability to screen electrocardiograms for its presence could improve detection and enable earlier diagnosis. This study evaluated the accuracy of an artificial intelligence device (viz HCM) in detecting HCM based on a 12-lead electrocardiogram.

Authors

  • James M Hillis
    Digital Clinical Research Organization, Data Science Office, Mass General Brigham, Boston, Massachusetts.
  • Bernardo C Bizzo
    Department of Radiology, Massachusetts General Hospital, Boston, MA, United States; Harvard Medical School, Boston, MA, United States; Mass General Brigham Data Science Office (DSO), Boston, MA, United States.
  • Sarah F Mercaldo
    Massachusetts General Hospital, Boston, Massachusetts.
  • Ankita Ghatak
    Mass General Brigham AI, Boston, Massachusetts.
  • Ashley L MacDonald
    Mass General Brigham AI, Boston, MA (J.M.H., B.C.B., S.F.M., A.G., A.L.M.D., M.A.H., A.S.S., E.L.I., V.T., K.J.D., B.M.S.).
  • Madeleine A Halle
    Mass General Brigham AI, Boston, MA (J.M.H., B.C.B., S.F.M., A.G., A.L.M.D., M.A.H., A.S.S., E.L.I., V.T., K.J.D., B.M.S.).
  • Alexander S Schultz
    Mass General Brigham AI, Boston, MA (J.M.H., B.C.B., S.F.M., A.G., A.L.M.D., M.A.H., A.S.S., E.L.I., V.T., K.J.D., B.M.S.).
  • Eric L'Italien
    Mass General Brigham AI, Boston, MA (J.M.H., B.C.B., S.F.M., A.G., A.L.M.D., M.A.H., A.S.S., E.L.I., V.T., K.J.D., B.M.S.).
  • Victor Tam
    Mass General Brigham AI, Boston, MA (J.M.H., B.C.B., S.F.M., A.G., A.L.M.D., M.A.H., A.S.S., E.L.I., V.T., K.J.D., B.M.S.).
  • Nicole K Bart
    Department of Cardiology, St Vincent's Hospital, Sydney, NSW, Australia; Victor Chang Cardiac Research Institute, Sydney, NSW, Australia; Department of Cardiology, University of New South Wales, Sydney, NSW, Australia; University of Notre Dame, Sydney, NSW, Australia. Electronic address: Nicole.bart@svha.org.au.
  • Filipe A Moura
    Harvard Medical School, Boston, MA (J.M.H., B.C.B., S.F.M., N.K.B., F.A.M., A.M.A., D.B., A.J.B., D.A.G., K.S.J., M.S.L., N.A.M., V.D.N., K.J.D., B.M.S., C.Y.H.).
  • Amine M Awad
    Department of Neurology, Massachusetts General Hospital, Boston, MA. (J.M.H., A.M.A., D.B.).
  • David Bargiela
    Department of Neurology, Massachusetts General Hospital, Boston, MA. (J.M.H., A.M.A., D.B.).
  • Sarajune Dagen
    Department of Neurosurgery, Brigham and Women's Hospital, Boston, MA. (S.D.).
  • Danielle Toland
    Department of Neurology, Brigham and Women's Hospital, Boston, MA. (A.M.A., D.B., D.T.).
  • Alexander J Blood
    Accelerator for Clinical Transformation, Brigham and Women's Hospital, Boston, MA.
  • David A Gross
    Harvard Medical School, Boston, MA (J.M.H., B.C.B., S.F.M., N.K.B., F.A.M., A.M.A., D.B., A.J.B., D.A.G., K.S.J., M.S.L., N.A.M., V.D.N., K.J.D., B.M.S., C.Y.H.).
  • Karola S Jering
    Cardiovascular Division, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
  • Mathew S Lopes
    Harvard Medical School, Boston, MA (J.M.H., B.C.B., S.F.M., N.K.B., F.A.M., A.M.A., D.B., A.J.B., D.A.G., K.S.J., M.S.L., N.A.M., V.D.N., K.J.D., B.M.S., C.Y.H.).
  • Nicholas A Marston
    Harvard Medical School, Boston, MA (J.M.H., B.C.B., S.F.M., N.K.B., F.A.M., A.M.A., D.B., A.J.B., D.A.G., K.S.J., M.S.L., N.A.M., V.D.N., K.J.D., B.M.S., C.Y.H.).
  • Victor D Nauffal
    Harvard Medical School, Boston, MA (J.M.H., B.C.B., S.F.M., N.K.B., F.A.M., A.M.A., D.B., A.J.B., D.A.G., K.S.J., M.S.L., N.A.M., V.D.N., K.J.D., B.M.S., C.Y.H.).
  • Keith J Dreyer
    Department of Radiology, Massachusetts General Hospital, Boston, MA, United States; Harvard Medical School, Boston, MA, United States; Mass General Brigham Data Science Office (DSO), Boston, MA, United States.
  • Benjamin M Scirica
    Accelerator for Clinical Transformation, Brigham and Women's Hospital, Boston, MA.
  • Carolyn Y Ho
    Cardiovascular Division, Brigham and Women's Hospital, USA.

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