Characterizing hub biomarkers for metabolic-induced endothelial dysfunction and unveiling their regulatory roles in EndMT through RNA sequencing and machine learning approaches.

Journal: Frontiers in cardiovascular medicine
Published Date:

Abstract

BACKGROUND: Metabolic disorder and endothelial dysfunction (ED) are key events in the development and pathophysiology of atherosclerosis and are associated with an elevated risk of Cardiovascular disease (CVD). The pathophysiology remains incompletely understood.

Authors

  • Qi Sun
    Department of Orthopedics, Shanghai Tenth People's Hospital, Tongji University, School of Medicine, Shanghai, 200072, P.R.China.
  • Longchuan Xie
    Clinical Molecular Diagnostic Center, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, China.
  • He An
    Department of Clinical Laboratory, Tianjin First Central Hospital, School of Medicine, Nankai University, Tianjin, China.
  • Wei Chen
    Department of Urology, Zigong Fourth People's Hospital, Sichuan, China.
  • Qirong Yang
    Clinical Molecular Diagnostic Center, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, China.
  • Peng Wang
    Neuroengineering Laboratory, School of Biomedical Engineering and Technology, Tianjin Medical University, Tianjin, China.
  • Yijun Tang
    Hubei Key Laboratory of Embryonic Stem Cell Research, Hubei Provincial Clinical Research Center for Umbilical Cord Blood Hematopoietic Stem Cells, Taihe Hospital, Hubei University of Medicine, Shiyan, China.
  • Chunyan Peng
    Department of Gastroenterology, Nanjing Drum Tower Hospital, Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210008, China; Department of Gastroenterology, Nanjing Drum Tower Hospital, Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing, Jiangsu 210008, China.

Keywords

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