Emerging strategies to develop novel genetically encoded biosensors.

Journal: Trends in biotechnology
Published Date: May 15, 2025

Abstract

The current biosensor inventory is inadequate for the multitude of metabolites and proteins needing detection. Assisted by new technologies and research paradigms such as multi-omics analysis and de novo protein design, emerging strategies provide a promising avenue for the development of novel, tailored genetically encoded biosensors for various applications.

Authors

  • Lili Chang
    University of Chinese Academy of Sciences, Beijing 100049, China; State Key Laboratory of Engineering Biology for Low-Carbon Manufacturing, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China.
  • Jin Wang
    Cells Vision (Guangzhou) Medical Technology Inc., Guangzhou, China. Electronic address: wangjin@cellsvision.com.
  • Meng Wang
    State Key Laboratory of Urban Water Resource and Environment, School of Environment, Harbin Institute of Technology, Harbin 150001, China.
  • Yue Zhang
    Department of Ophthalmology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.

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