Comparing methods to improve cone-beam computed tomography for dose calculations in adaptive proton therapy.

Journal: Physics and imaging in radiation oncology
Published Date: May 16, 2025

Abstract

BACKGROUND AND PURPOSE: Proton therapy requires dose monitoring, often performed based on repeated computed tomography (reCT) scans. However, reCT scans may not accurately reflect the internal anatomy and patient positioning during treatment. In-room cone-beam CT (CBCT) offers a potential alternative, but its low image quality limits proton dose calculation accuracy. This study therefore evaluated different methods for quality-improvement of CBCTs (synthetic CTs; sCTs) for use in adaptive proton therapy of head-and-neck cancer patients.

Authors

  • Casper Dueholm Vestergaard
    Danish Centre for Particle Therapy, Aarhus University Hospital, Aarhus, Denmark.
  • Nadine Vatterodt
    Danish Centre for Particle Therapy, Aarhus University Hospital, Aarhus, Denmark.
  • Ulrik Vindelev Elstrøm
    Danish Centre of Particle Therapy, Aarhus University Hospital, Aarhus, Denmark.
  • Kenneth Jensen
    Danish Centre of Particle Therapy, Aarhus University Hospital, Aarhus, Denmark.
  • Ole Nørrevang
    Danish Center for Particle Therapy, Aarhus University Hospital, Aarhus, Denmark.
  • Ludvig Paul Muren
    Danish Centre for Particle Therapy, Aarhus University Hospital, Aarhus, Denmark.
  • Stine Sofia Korreman
    Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
  • Vicki Trier Taasti
    Danish Centre for Particle Therapy, Aarhus University Hospital, Aarhus, Denmark.

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