Detection of Undiagnosed Liver Cirrhosis via Artificial Intelligence-Enabled Electrocardiogram (DULCE): Rationale and design of a pragmatic cluster randomized clinical trial.

Journal: Contemporary clinical trials communications
Published Date: Jun 1, 2025

Abstract

BACKGROUND: Cirrhosis is a leading cause of morbidity and mortality worldwide, yet preventable at early stages. Currently, effective approaches for early diagnosis are lacking. A novel electrocardiogram (ECG)-enabled deep learning model trained for detection of advanced chronic liver disease (CLD) has demonstrated promising results and it may be used for screening of advanced CLD in primary care.

Authors

  • Amy Olofson
    Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA.
  • Ryan Lennon
    Division of Biostatistics, Mayo Clinic College of Medicine, Rochester, Minnesota.
  • Blake Kassmeyer
    Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, USA.
  • Kan Liu
    Department of Urology, Hunan Cancer Hospital, Changsha, Hunan, China.
  • Zacchi I Attia
    Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA.
  • David Rushlow
    Department of Family Medicine, Mayo Clinic, Rochester, MN, USA.
  • Puru Rattan
    Department of Medicine, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MA, USA.
  • Joseph C Ahn
    Department of Medicine, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MA, USA.
  • Paul A Friedman
    Department of Cardiovascular Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota, USA.
  • Alina Allen
    Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA.
  • Patrick S Kamath
    Department of Medicine, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MA, USA.
  • Vijay H Shah
    Department of Medicine, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MA, USA.
  • Peter A Noseworthy
    Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota.
  • Douglas A Simonetto
    Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota.

Keywords

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