Can large language models detect drug-drug interactions leading to adverse drug reactions?

Journal: Therapeutic advances in drug safety
Published Date: May 16, 2025

Abstract

BACKGROUND: Drug-drug interactions (DDI) are an important cause of adverse drug reactions (ADRs). Could large language models (LLMs) serve as valuable tools for pharmacovigilance specialists in detecting DDIs that lead to ADR notifications?

Authors

  • Justine Sicard
    Department of Medical and Clinical Pharmacology, Centre of PharmacoVigilance and Pharmacoepidemiology, Faculty of Medicine, Toulouse University Hospital (CHU), Toulouse, France.
  • François Montastruc
    Department of Medical and Clinical Pharmacology, Centre of Pharmacovigilance and Pharmacoepidemiology, Faculty of Medicine, Toulouse University Hospital (CHU), Toulouse, France.
  • Coline Achalme
    Department of Medical and Clinical Pharmacology, Centre of PharmacoVigilance and Pharmacoepidemiology, Faculty of Medicine, Toulouse University Hospital (CHU), Toulouse, France.
  • Annie Pierre Jonville-Bera
    Department of Medical and Clinical Pharmacology, Tours University Hospital (CHU), Tours, France.
  • Paul Songue
    Department of Medical and Clinical Pharmacology, Centre of PharmacoVigilance and Pharmacoepidemiology, Faculty of Medicine, Toulouse University Hospital (CHU), Toulouse, France.
  • Marina Babin
    Regional Pharmacovigilance Centre, Angers University Hospital (CHU), Angers, France.
  • Thomas Soeiro
    Regional Pharmacovigilance Centre, Marseille University Hospital (CHU), Marseille, France.
  • Pauline Schiro
    Department of Medical and Clinical Pharmacology, Centre of PharmacoVigilance and Pharmacoepidemiology, Faculty of Medicine, Toulouse University Hospital (CHU), Toulouse, France.
  • Claire de Canecaude
    Department of Medical and Clinical Pharmacology, Centre of Pharmacovigilance and Pharmacoepidemiology, Faculty of Medicine, Toulouse University Hospital (CHU), Toulouse, France.
  • Romain Barus
    Department of Medical and Clinical Pharmacology, Centre of Pharmacovigilance and Pharmacoepidemiology, Faculty of Medicine, Toulouse University Hospital (CHU), Toulouse, France. romain.barus@univ-tlse3.fr.

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