Fibrogenesis-driven tumor progression in clear cell renal cell carcinoma: prognostic, therapeutic implications and the dual role of neuropilin-1.

Journal: Cancer cell international
Published Date: May 16, 2025

Abstract

BACKGROUND: Clear cell renal cell carcinoma (ccRCC) is the predominant subtype of renal cancer, with a poor prognosis driven by therapy resistance and a propensity for recurrence. Tumor microenvironment (TME)-associated fibrosis accelerates disease progression by fostering immune evasion. Neuropilin-1 (NRP1), a key mediator in fibrotic signaling and cancer biology, has been implicated in these processes. However, the genetic correlation between fibrogenesis and ccRCC remains largely unexplored, necessitating a focused analysis of fibrogenesis-related genes (FRGs) to identify novel prognostic markers and therapeutic strategies.

Authors

  • Kai Wang
    Department of Rheumatology, The Affiliated Huai'an No. 1 People's Hospital of Nanjing Medical University, Huai'an, Jiangsu, China.
  • Xihao Shen
    Department of Urology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
  • Jiyue Wu
    Department of Urology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
  • Qing Bi
    Department of Urology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
  • Zihao Gao
    Department of Urology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
  • Zejia Sun
    Department of Urology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
  • Wei Wang
    State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau 999078, China.

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