FDG-PET intensity normalization improves radiomics- based survival prediction in oropharyngeal cancer patients: a comparison of the SUV with alternative normalization techniques.

Journal: AJNR. American journal of neuroradiology
Published Date:

Abstract

BACKGROUND AND PURPOSE: Despite the widespread research application of radiomics, there is a knowledge gap regarding the optimal voxel intensity normalization strategy for FDG-PET radiomics. We investigated the impact of three normalization strategies on the prognostic utility of individual radiomic features and machine learning models in oropharyngeal squamous cell carcinoma (OPSCC) patients.

Authors

  • Seyedmehdi Payabvash
    Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA.
  • Kariem Sharaf
    Department of Otorhinolaryngology, LMU Clinic of Ludwig Maximilians University of Munich, Munich, Germany.
  • Tal Zeevi
    Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Connecticut.
  • Moritz Gross
    Department of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, CT, USA. moritz.gross@charite.de.
  • Amit Mahajan
    Department of Radiology, Yale School of Medicine, New Haven, CT.
  • Benjamin H Kann
    Artificial Intelligence in Medicine (AIM) Program, Harvard Medical School, Boston, Massachusetts, USA.
  • Benjamin L Judson
    Division of Otolaryngology, Yale School of Medicine, New Haven, Connecticut.
  • Andrea Schreier
    From the Department of Radiology, Columbia University Medical Center, New York, NY, USA (Seyedmehdi Payabvash, MD), Department of Otorhinolaryngology, LMU Clinic of Ludwig-Maximilians-University of Munich, Munich, Germany (Kariem Sharaf, MD, DDS; Andrea Schreier, MD; Jasmin Krenn; Martin Canis, MD; Philipp Baumeister, MD; Christoph A. Reichel, MD; Stefan P. Haider, MD), Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA (Tal Zeevi, MSc; Moritz Gross; Amit Mahajan, MD; Stefan P. Haider, MD), Charité Center for Diagnostic and Interventional Radiology, Charité-Universitätsmedizin Berlin, Berlin, Germany (Moritz Gross), Department of Radiation Oncology, Dana-Farber- Cancer-Institute, Harvard Medical School, Boston, MA, USA (Benjamin H. Kann, MD), Division of Otolaryngology, Yale School of Medicine, New Haven, CT, USA (Benjamin L. Judson, MD), Department of Pathology, Yale School of Medicine, New Haven, CT, USA (Manju L. Prasad, MD), Section of Medical Oncology, Yale School of Medicine, New Haven, CT, USA (Barbara Burtness, MD), Bavarian Cancer Research Center (BZKF), Munich, Germany (Philipp Baumeister, MD), and Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, PA, USA (Mariam Aboian, MD/PhD).
  • Jasmin Krenn
    From the Department of Radiology, Columbia University Medical Center, New York, NY, USA (Seyedmehdi Payabvash, MD), Department of Otorhinolaryngology, LMU Clinic of Ludwig-Maximilians-University of Munich, Munich, Germany (Kariem Sharaf, MD, DDS; Andrea Schreier, MD; Jasmin Krenn; Martin Canis, MD; Philipp Baumeister, MD; Christoph A. Reichel, MD; Stefan P. Haider, MD), Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA (Tal Zeevi, MSc; Moritz Gross; Amit Mahajan, MD; Stefan P. Haider, MD), Charité Center for Diagnostic and Interventional Radiology, Charité-Universitätsmedizin Berlin, Berlin, Germany (Moritz Gross), Department of Radiation Oncology, Dana-Farber- Cancer-Institute, Harvard Medical School, Boston, MA, USA (Benjamin H. Kann, MD), Division of Otolaryngology, Yale School of Medicine, New Haven, CT, USA (Benjamin L. Judson, MD), Department of Pathology, Yale School of Medicine, New Haven, CT, USA (Manju L. Prasad, MD), Section of Medical Oncology, Yale School of Medicine, New Haven, CT, USA (Barbara Burtness, MD), Bavarian Cancer Research Center (BZKF), Munich, Germany (Philipp Baumeister, MD), and Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, PA, USA (Mariam Aboian, MD/PhD).
  • Manju L Prasad
    Department of Pathology, Yale School of Medicine, New Haven, Connecticut; and.
  • Barbara Burtness
    Section of Medical Oncology, Yale School of Medicine, New Haven, Connecticut.
  • Mariam Aboian
    Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT.
  • Martin Canis
    Research Unit Radiation Cytogenetics, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, Neuherberg, Germany; Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital, LMU Munich, Munich, 81377, Germany.
  • Philipp Baumeister
    Klinik für Urologie, Luzerner Kantonsspital, Luzern, Switzerland.
  • Christoph A Reichel
    Department of Otorhinolaryngology, LMU Clinic of Ludwig Maximilians University of Munich, Munich, Germany.
  • Stefan P Haider
    Department of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, CT, USA.

Keywords

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