Whispers beneath the skin: how microneedles are shaping tomorrow's therapies.
Journal:
Journal of biomaterials science. Polymer edition
Published Date:
May 18, 2025
Abstract
Microneedles (MNs) offer a minimally invasive alternative to conventional patch-based and injection-based drug delivery methods. By bypassing first-pass metabolism and enhancing skin permeability, MNs significantly improve drug bioavailability. Their applications span vaccine administration, chronic disease management, and cosmetic treatments. Five major types of MNs have been identified, each with distinct mechanisms of action. Recent research focuses on advanced manufacturing techniques, stimuli-responsive materials, and combination drug therapies. Common materials include silicon, hydrogels, and biodegradable polymers, with growing interest in sustainable alternatives. Despite their potential, MNs face challenges related to drug stability, cost-effective production, and regulatory approvals. Emerging technologies, such as The integration of 3D printing, artificial intelligence, and biosensing technologies is driving significant advancements in personalized medicine. Clinical trials involving vaccines, biologics, and gene therapies are accelerating their path toward regulatory acceptance. MNs support patient self-administration, reduce dependency on healthcare infrastructure, and expand global access to treatment. Their integration with telemedicine and remote drug monitoring positions them as a transformative tool in future medical practice.
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