Development and validation of a multiple myeloma diagnostic model based on systemic lupus erythematosus-associated genes and identification of specific genes.
Journal:
Discover oncology
Published Date:
May 18, 2025
Abstract
BACKGROUND: Monoclonal immunoglobulins are commonly found in multiple myeloma (MM), a prevalent hematologic malignancy that is currently incurable. In recent years, the association between systemic lupus erythematosus (SLE), an autoimmune disease, and MM has garnered increasing attention. However, there remains a lack of in-depth research regarding the interactions between these two conditions and their potential pathogenic mechanisms. Therefore, in order to improve the identification of MM associated with SLE, this work attempts to clarify the pathogenic pathways that are shared by MM and SLE and to develop corresponding diagnostic models.
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