Whole-Blood RNA Sequencing Profiling of Patients With Rheumatoid Arthritis Treated With Tofacitinib.

Journal: ACR open rheumatology
Published Date:

Abstract

OBJECTIVE: Patients with rheumatoid arthritis (RA) often fail to respond to therapies, including JAK inhibitors (JAKi), and treatment allocation is made via a trial-and-error strategy. A comprehensive analysis of responses to JAKi, including tofacitinib, by RNA sequencing (RNAseq) would allow the discovery of transcriptomic markers with a two-fold meaning: (1) an improved knowledge about the mechanisms of response to treatment (inference modeling) and (2) the definition of features that may be useful in treatment optimization and assignment (predictive modeling).

Authors

  • Chiara Bellocchi
    Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico and University of Milan, Milan, Italy.
  • Ennio Giulio Favalli
    University of Milan and ASST PiniCTO - Presidio Gaetano Pini, Milan, Italy.
  • Gabriella Maioli
    University of Milan and ASST PiniCTO - Presidio Gaetano Pini, Milan, Italy.
  • Elena Agape
    University of Milan, Milan, Italy.
  • Marzia Rossato
    University of Verona, Verona, Italy.
  • Matteo Paini
    University of Verona, Verona, Italy.
  • Adriana Severino
    Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
  • Barbara Vigone
    Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
  • Martina Biggioggero
    ASST PiniCTO - Presidio Gaetano Pini, Milan, Italy.
  • Elena Trombetta
    Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
  • Roberto Caporali
    University of Milan and ASST PiniCTO - Presidio Gaetano Pini, Milan, Italy.
  • Lorenzo Beretta
    Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

Keywords

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