Integrative Metabolomic and Lipidomic Signatures of SARS-CoV-2 VOCs: Correlations with Hematological and Biochemical Markers.

Journal: Journal of proteome research
Published Date: May 19, 2025

Abstract

In the present study, we investigated biochemical, hematological, lipidomic, and metabolomic alterations associated with different SAR-CoV-2 variants of concern (VOCs), such as WT, α, β, γ, and δ, as well as their impact on COVID-19 severity. Across the first and second waves in India, a machine learning approach was used in 3134 COVID-19 patients, and nine critical biochemical and hematological parameters, namely, C-reactive protein (CRP), D-dimer, ferritin, neutrophil, WBC count, lymphocyte, urea, creatine, and lactate dehydrogenase (LDH), were identified. Furthermore, through metabolic and lipidomic profiles of lung and colon cells transfected with spike VOCs, notable dysregulation was exhibited by the delta variant correlated with characteristic pathways such as catecholamine and thyroid hormone synthesis. A corroborating meta-analysis also highlighted the involvement of urea and amino acid metabolism pathways. Overall, our study provides crucial insights into metabolic and biochemical disruptions caused by VOCs, contributing to a better understanding of COVID-19 pathogenesis and the development of targeted interventions.

Authors

  • Budhadev Baral
  • Vaishali Saini
    Infection Bioengineering Group, Department of Biosciences and Biomedical Engineering, Indian Institute of Technology Indore, Simrol, Indore, Madhya Pradesh 453552, India.
  • Siddharth Singh
    Division of Gastroenterology, Department of Medicine, University of California San Diego, La Jolla, CA, USA.
  • Tarun Prakash Verma
    Infection Bioengineering Group, Department of Biosciences and Biomedical Engineering, Indian Institute of Technology Indore, Simrol, Indore, Madhya Pradesh 453552, India.
  • Deb Kumar Rath
    Materials and Device Lab, Department of Physics, Indian Institute of Technology Indore, Simrol, Indore, Madhya Pradesh 453552, India.
  • Jyotirmayee Bahinipati
    Department of Biochemistry, Kalinga Institute of Medical Sciences, KIIT Deemed to be University, Bhubaneswar, Odisha 751024, India.
  • Priyadarsini Panda
    School of Biotechnology, Kalinga Institute of Industrial Technology (KIIT), Deemed to be University, Bhubaneswar, Odisha 751024, India.
  • Shubhransu Patro
  • Namrata Misra
  • Manas Ranjan Behera
    Department of Pediatrics, Kalinga Institute of Medical Sciences, KIIT Deemed to be University, Bhubaneswar, Odisha 751024, India.
  • Kartik Muduli
  • Hamendra Singh Parmar
  • Ajay Kumar Meena
    Regional Ayurveda Research Institute, Amkhoh, Gwalior, Madhya Pradesh 474001, India.
  • Rajesh Kumar
    Johns Hopkins University (JHU), Baltimore, MD 21218, USA.
  • Sonali Agarwal
    Department of Information Technology, Indian Institute of Information Technology, Allahabad, India.
  • Soumya R Mohapatra
    School of Biotechnology, Kalinga Institute of Industrial Technology (KIIT), Deemed to be University, Bhubaneswar, Odisha 751024, India.
  • Nirmal Kumar Mohakud
  • Hem Chandra Jha

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