Assisting the Diagnosis of Cirrhosis in Chronic Hepatitis C Patients Based on Machine Learning Algorithms: A Novel Non-Invasive Approach.

Journal: Journal of clinical laboratory analysis
Published Date:

Abstract

AIM: This study aimed to determine the important features and cut-off values after demonstrating the detectability of cirrhosis using routine laboratory test results of chronic hepatitis C (CHC) patients in machine learning (ML) algorithms.

Authors

  • Emre Dirican
    Department of Biostatistics, Faculty of Medicine, Hatay Mustafa Kemal University, Hatay, Turkey.
  • Tayibe Bal
    Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Abant Izzet Baysal University, Bolu, Turkey. Electronic address: dr.tayibal@gmail.com.
  • Yusuf Onlen
    Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Bolu Abant Izzet Baysal University, Bolu, Turkey.
  • Figen Sarigul
    Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Akdeniz University, Antalya, Turkey.
  • Ulku User
    Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Akdeniz University, Antalya, Turkey.
  • Nagehan Didem Sari
    Department of Infectious Diseases and Clinical Microbiology, Health Sciences University, Istanbul Training and Research Hospital, Istanbul, Turkey.
  • Behice Kurtaran
    Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Cukurova University, Adana, Turkey.
  • Ebubekir Senates
    Department of Gastroenterology, Medicana International Istanbul Hospital, Istanbul, Turkey.
  • Alper Gunduz
    Sisli Hamidiye Etfal Research and Training Hospital Department of Infectious Diseases and Clinical Microbiology.
  • Esra Zerdali
    Department of Infectious Diseases and Clinical Microbiology, Health Sciences University, Haseki Training and Research Hospital, Istanbul, Turkey.
  • Hasan Karsen
    Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Harran University, Sanlıurfa, Turkey.
  • Ayse Batirel
    Department of Infectious Diseases and Clinical Microbiology, Health Sciences University, Dr. Lutfi Kirdar Kartal Training and Research Hospital, Istanbul, Turkey.
  • Ridvan Karaali
    Department of Infectious Diseases and Clinical Microbiology, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey.
  • Hatice Rahmet Guner
    Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Ankara Yildirim Beyazit University, Ankara City Hospital, Ankara, Turkey.
  • Tansu Yamazhan
    Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Ege University, Izmir, Turkey.
  • Sukran Kose
    Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Dokuz Eylül University, Izmir, Turkey.
  • Nurettin Erben
    Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Eskisehir Osmangazi University, Eskisehir, Turkey.
  • Nevin Koc Ince
    Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Duzce University, Duzce, Turkey.
  • Iftihar Koksal
    Department of Infectious Diseases and Clinical Microbiology, Acibadem University, Atakent Hospital, Istanbul, Turkey.
  • Nefise Oztoprak
    Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Akdeniz University, Antalya, Turkey.
  • Gulsen Yoruk
    Department of Infectious Diseases and Clinical Microbiology, Health Sciences University, Istanbul Training and Research Hospital, Istanbul, Turkey.
  • Suheyla Komur
    Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Cukurova University, Adana, Turkey.
  • Sibel Yildiz Kaya
    Department of Infectious Diseases and Clinical Microbiology, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, Corum, Turkey.
  • Ilkay Bozkurt
    Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Ondokuz Mayis University, Samsun, Turkey.
  • Ozgur Gunal
    Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Samsun University, Samsun, Turkey.
  • Ilknur Esen Yildiz
    Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Recep Tayyip Erdoğan University, Rize, Turkey.
  • Dilara Inan
    Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Akdeniz University, Antalya, Turkey.
  • Sener Barut
    Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Dokuz Eylül University, Izmir, Turkey.
  • Mustafa Namiduru
    Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Gaziantep University, Gaziantep, Turkey.
  • Selma Tosun
    Department of Infectious Diseases and Clinical Microbiology, Health Sciences University, Bozyaka Training and Research Hospital, Izmir, Turkey.
  • Kamuran Turker
    Department of Infectious Diseases and Clinical Microbiology, Health Sciences University, Bağcılar Training and Research Hospital, Istanbul, Turkey.
  • Alper Sener
    Department of Infectious Diseases and Clinical Microbiology, Health Sciences University, Izmir Katip Celebi Training and Research Hospital, Izmir, Turkey.
  • Kenan Hizel
    Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Gazi University, Ankara, Turkey.
  • Nurcan Baykam
    Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Hitit University, Corum, Turkey.
  • Fazilet Duygu
    Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Gaziosmanpaşa University, Tokat, Germany.
  • Hürrem Bodur
    Department of Infectious Diseases and Clinical Microbiology, University of Health Sciences Turkey, Gülhane Faculty of Medicine, Ankara City Hospital, Ankara, Turkey.
  • Guray Can
    Department of Gastroenterology, Faculty of Medicine, Abant Izzet Baysal University, Bolu, Turkey.
  • Hanefi Cem Gul
    Department of Infectious Diseases and Clinical Microbiology, Health Sciences University, Gülhane Training and Research Hospital, Ankara, Turkey.
  • Ayse Sagmak Tartar
    Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Fırat University, Elazıg, Turkey.
  • Guven Celebi
    Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Zonguldak Bulent Ecevit University, Zonguldak, Turkey.
  • Mahmut Sunnetcioglu
    Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Sakarya University, Sakarya, Turkey.
  • Oguz Karabay
    Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Sakarya University, Sakarya, Turkey.
  • Hayat Kumbasar Karaosmanoglu
    Department of Infectious Diseases and Clinical Microbiology, Health Sciences University, Bakırköy Dr. Sadi Konuk Training and Research Hospital, Istanbul, Turkey.
  • Fatma Sirmatel
    Department of Internal Medicine, Division of Infectious Diseases, Izmir Tınaztepe University Faculty of Medicine, İzmir, Turkey.
  • Omer Fehmi Tabak
    Department of Infectious Diseases and Clinical Microbiology, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey.

Keywords

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