Functional MRI Analysis of Cortical Regions to Distinguish Lewy Body Dementia From Alzheimer's Disease.

Journal: The Journal of neuropsychiatry and clinical neurosciences
Published Date: May 19, 2025

Abstract

OBJECTIVE: Cortical regions such as parietal area H (PH) and the fundus of the superior temporal sulcus (FST) are involved in higher visual function and may play a role in dementia with Lewy bodies (DLB), which is frequently associated with hallucinations. The authors evaluated functional connectivity between these two regions for distinguishing participants with DLB from those with Alzheimer's disease (AD) or mild cognitive impairment (MCI) and from cognitively normal (CN) individuals to identify a functional connectivity MRI signature for DLB.

Authors

  • Bhavani Kashyap
    HealthPartners Institute, Bloomington, Minn. (Kashyap, Hanson, Gustafson, Sherman); HealthPartners Center for Memory and Aging, St. Paul, Minn. (Kashyap, Hanson, Sherman); Omniscient Neurotechnology, Atlanta (Sughrue); Department of Neurology, Center for Memory and Brain Wellness, University of Washington, Seattle (Rosenbloom).
  • Leah R Hanson
    HealthPartners Institute, Bloomington, Minn. (Kashyap, Hanson, Gustafson, Sherman); HealthPartners Center for Memory and Aging, St. Paul, Minn. (Kashyap, Hanson, Sherman); Omniscient Neurotechnology, Atlanta (Sughrue); Department of Neurology, Center for Memory and Brain Wellness, University of Washington, Seattle (Rosenbloom).
  • Sally K Gustafson
    HealthPartners Institute, Bloomington, Minn. (Kashyap, Hanson, Gustafson, Sherman); HealthPartners Center for Memory and Aging, St. Paul, Minn. (Kashyap, Hanson, Sherman); Omniscient Neurotechnology, Atlanta (Sughrue); Department of Neurology, Center for Memory and Brain Wellness, University of Washington, Seattle (Rosenbloom).
  • Samantha J Sherman
    HealthPartners Institute, Bloomington, Minn. (Kashyap, Hanson, Gustafson, Sherman); HealthPartners Center for Memory and Aging, St. Paul, Minn. (Kashyap, Hanson, Sherman); Omniscient Neurotechnology, Atlanta (Sughrue); Department of Neurology, Center for Memory and Brain Wellness, University of Washington, Seattle (Rosenbloom).
  • Michael E Sughrue
    Omniscient Neurotechnology, Sydney, Australia.
  • Michael H Rosenbloom
    HealthPartners Institute, Bloomington, Minn. (Kashyap, Hanson, Gustafson, Sherman); HealthPartners Center for Memory and Aging, St. Paul, Minn. (Kashyap, Hanson, Sherman); Omniscient Neurotechnology, Atlanta (Sughrue); Department of Neurology, Center for Memory and Brain Wellness, University of Washington, Seattle (Rosenbloom).

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