FDG-PET as a pre-operative biomarker for predicting and optimizing response to subcallosal cingulate area deep brain stimulation.

Journal: Biological psychiatry
Published Date: May 20, 2025

Abstract

BACKGROUND: Deep brain stimulation targeting the subcallosal cingulate area (SCC-DBS) has emerged as a promising therapy for treatment-resistant depression (TRD). However, only half to two thirds of patients experience meaningful clinical response, highlighting the need for biomarkers that could help to optimize SCC-DBS outcomes. Our group previously showed that a support vector machine (SVM) incorporating pre-operative FDG-PET glucose metabolism values from frontal pole, anterior cingulate cortex, and temporal pole could retrospectively classify treatment response in 21 TRD patients with 81.0% accuracy. Here, we assessed the out-of-sample performance and wider applicability of this putative biomarker.

Authors

  • Gavin J B Elias
    Division of Neurosurgery, Department of Surgery, University Health Network and University of Toronto, Toronto, ON, Canada.
  • Sarah A Iskin
    Division of Neurosurgery, Department of Surgery, University of Toronto & University Hospital Network, Toronto, Canada.
  • Michelle E Beyn
    Division of Neurosurgery, Department of Surgery, University of Toronto & University Hospital Network, Toronto, Canada.
  • Uyiosa Omere
    Division of Neurosurgery, Department of Surgery, University of Toronto & University Hospital Network, Toronto, Canada.
  • Sakina J Rizvi
    Department of Psychiatry, University Health Network & University of Toronto, Toronto, Canada.
  • Amanda K Ceniti
    Master of Arts Program in the Social Sciences (MAPSS), University of Chicago, Chicago, USA.
  • Alexandre Boutet
    Joint Department of Medical Imaging, University of Toronto, Toronto, Canada.
  • Daphne Voineskos
    Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada.
  • Sidney H Kennedy
    Department of Psychiatry, University of Toronto, Toronto, ON, Canada.
  • Andres M Lozano
    Division of Neurosurgery, Department of Surgery, University Health Network and University of Toronto, Toronto, ON, Canada. lozano@uhnresearch.ca.
  • Jurgen Germann
    Division of Neurosurgery, Department of Surgery, University Health Network and University of Toronto, Toronto, ON, Canada.

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