Development and validation of an artificial intelligence-based pipeline for predicting oral epithelial dysplasia malignant transformation.

Journal: Communications medicine
Published Date: May 20, 2025

Abstract

BACKGROUND: Oral epithelial dysplasia (OED) is a potentially malignant histopathological diagnosis given to lesions of the oral cavity that are at risk of progression to malignancy. Manual grading of OED is subject to substantial variability and does not reliably predict prognosis, potentially resulting in sub-optimal treatment decisions.

Authors

  • Adam J Shephard
    Tissue Image Analytics Centre, Department of Computer Science, University of Warwick, Coventry, UK.
  • Hanya Mahmood
    Academic Unit of Oral & Maxillofacial Surgery, School of Clinical Dentistry, University of Sheffield, Sheffield, UK. h.mahmood@sheffield.ac.uk.
  • Shan E Ahmed Raza
    Division of Molecular Pathology, The Institute of Cancer Research, UK; Department of Computer Science, University of Warwick, UK; Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK. Electronic address: shan.raza@icr.ac.uk.
  • Anna Luíza Damaceno Araújo
    Oral Diagnosis Department, Piracicaba Dental School, University of Campinas (FOP-UNICAMP), Piracicaba, São Paulo, Brazil.
  • Alan Roger Santos-Silva
    Oral Diagnosis Department (Pathology and Semiology), Piracicaba Dental School, University of Campinas, Piracicaba, Brazil.
  • Márcio Ajudarte Lopes
    Oral Diagnosis Department (Pathology and Semiology), Piracicaba Dental School, University of Campinas, Piracicaba, Brazil.
  • Pablo Agustin Vargas
    Oral Diagnosis Department, Piracicaba Dental School, University of Campinas (FOP-UNICAMP), Piracicaba, São Paulo, Brazil.
  • Kris D McCombe
    Precision Medicine Centre, Patrick G. Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK.
  • Stephanie G Craig
    Precision Medicine Centre, Patrick G. Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK.
  • Jacqueline James
    School of Medicine Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, United Kingdom.
  • Jill Brooks
    Institute of Head and Neck Studies and Education, Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.
  • Paul Nankivell
    Institute of Head and Neck Studies and Education, Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.
  • Hisham Mehanna
    Institute for Head and Neck Studies and Education (Inhanse), University of Birmingham, Birmingham, United Kingdom.
  • Syed Ali Khurram
    Senior Clinical Lecturer, Consultant Oral Pathologist, University of Sheffield, Sheffield, UK.
  • Nasir M Rajpoot

Keywords

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