The role of phenotypic age acceleration in aneurysmal subarachnoid hemorrhage: analysis of retrospective data from two hospital-based cohorts and prospective UK Biobank cohort.

Journal: International journal of surgery (London, England)
Published Date: May 20, 2025

Abstract

BACKGROUND: Phenotypic age acceleration (PhenoAgeAccel) is considered a major risk factor for various age-related diseases, but its specific role in aneurysmal subarachnoid hemorrhage (aSAH) remains unclear. This study aims to examine the relationship between PhenoAgeAccel and the risk of aSAH, and further explores whether genetic susceptibility modifies this association.

Authors

  • Jiarong He
    Department of Neurosurgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
  • Yuquan Chen
    Department of Neurosurgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
  • Sidi Xu
    Department of Neurosurgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
  • Pengwei Hou
    Department of Neurosurgery, Jinjiang Municipal Hospital (Shanghai Sixth People's Hospital Fujian), Huaqiao University, Jinjiang, Fujian, China.
  • Yan Cui
    .
  • Kai Su
    Department of Oral and Maxillofacial Surgery, Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, Guangzhou, Guangdong, China; Guangdong Province Key Laboratory of Stomatology, Guangzhou, Guangdong, China.
  • Xieli Guo
    Department of Neurosurgery, Jinjiang Municipal Hospital (Shanghai Sixth People's Hospital Fujian), Huaqiao University, Jinjiang, Fujian, China.
  • Ming Wang
    Brain center, Zhejiang Hospital, Hangzhou, China.
  • Mingming Zhang
    Department of Gastroenterology, Qilu Hospital of Shandong University, Jinan, Shandong, China.

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