Towards automating risk stratification of intraductal papillary mucinous Neoplasms: Artificial intelligence advances beyond human expertise with confocal laser endomicroscopy.

Journal: Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]
Published Date:

Abstract

BACKGROUND AND AIMS: Endoscopic Ultrasound (EUS)-guided needle-based confocal laser endomicroscopy (nCLE) enables real-time microscopic visualization of pancreatic cyst epithelium and can identify high-grade dysplasia/invasive adenocarcinoma (HGD/IC) in branch-duct (BD) intraductal papillary mucinous neoplasms (IPMNs). We aimed to compare the performance of experts (humans) with artificial intelligence (AI) in stratifying dysplasia in BD-IPMNs.

Authors

  • Somashekar G Krishna
    Division of Gastroenterology, Hepatology, and Nutrition, Division of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
  • Ahmed Abdelbaki
    Division of Gastroenterology, Hepatology, and Nutrition, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
  • Ziwei Li
    Faculty of Environment and Life Sciences, Beijing University of Technology, Beijing 100124, China.
  • Stacey Culp
    Department of Bioinformatics, Ohio State University Wexner Medical Center, Columbus, Ohio, United States of America.
  • Xinqi Xiong
    Department of Statistics, College of Arts and Sciences, Ohio State University, USA.
  • Bertrand Napoleon
    Department of Gastroenterology, Jean Mermoz Private Hospital, Ramsay Sante, France.
  • Shaffer Mok
    Division of Gastrointestinal Oncology, Moffitt Cancer Center, Tampa, FL, USA.
  • Helga Bertani
    Gastroenterology and Endoscopy Unit, Azienda Ospedaliero Universitaria Policlinico di Modena, Modena, Italy.
  • Yunlu Feng
    Department of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
  • Pradermchai Kongkam
    King Chulalongkorn Memorial Hospital, Bangkok, Thailand.
  • Anjuli K Luthra
    Division of Gastrointestinal Oncology, Moffitt Cancer Center, Tampa, FL, USA.
  • Jorge D Machicado
    Division of Gastroenterology and Hepatology, Mayo Clinic Health System, Eau Claire, Wisconsin, USA.
  • Samer El-Dika
    Division of Gastroenterology and Hepatology, Stanford University, Stanford, CA, USA.
  • Sarah Leblanc
    Department of Gastroenterology, Jean Mermoz Private Hospital, Ramsay Sante, France.
  • Damien Meng Yew Tan
    Department of Gastroenterology and Hepatology, Singapore General Hospital, Singapore.
  • Jordan Burlen
    Division of Gastroenterology, Hepatology, and Nutrition, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
  • Margaret G Keane
  • Tara Keihanian
    Section of Gastroenterology, Baylor College of Medicine, Houston, TX, USA.
  • Antonio Mendoza Ladd
    Division of Gastroenterology and Hepatology at University of California Davis, Sacramento, CA, USA.
  • Thiruvengadam Muniraj
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA.
  • Kavel H Visrodia
    Division of Digestive and Liver Diseases, Department of Medicine, Columbia University Irving Medical Center, NY, USA.
  • Wei Chen
    Department of Urology, Zigong Fourth People's Hospital, Sichuan, China.
  • Ashwini K Esnakula
    Department of Pathology, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
  • Phil A Hart
    Division of Gastroenterology, Hepatology, and Nutrition, Division of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
  • Wei-Lun Chao
    Department of Computer Science and Engineering, College of Engineering, The Ohio State University, Columbus, Ohio, USA.

Keywords

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