Mechanically assisted non-invasive ventilation for liver SABR: Improve CBCT, treat more accurately.

Journal: Clinical and translational radiation oncology
Published Date: Jul 1, 2025

Abstract

BACKGROUND AND PURPOSE: Cone-beam computed tomography (CBCT) for image-guided radiotherapy (IGRT) during liver stereotactic ablative radiotherapy (SABR) is degraded by respiratory motion artefacts, potentially jeopardising treatment accuracy. Mechanically assisted non-invasive ventilation-induced breath-hold (MANIV-BH) can reduce these artefacts. This study compares MANIV-BH and free-breathing CBCTs regarding image quality, IGRT variability, automatic registration accuracy, and deep-learning auto-segmentation performance.

Authors

  • Julien Pierrard
    Institut de Recherche Experimentale et Clinique (IREC), Center of Molecular Imaging, Radiotherapy and Oncology (MIRO), Université Catholique de Louvain, Brussels, Belgium.
  • Nicolas Audag
    Institut de Recherche Expérimentale et Clinique (IREC), Pôle de Pneumologie, ORL (airways) & Dermatologie (skin), Groupe Recherche en Kinésithérapie Respiratoire, Université Catholique de Louvain, Brussels, Belgium.
  • Christel Abdel Massih
    Department of Radiation Oncology, Cliniques Universitaires Saint-Luc, Brussels, Belgium.
  • Maria Alvear Garcia
    Department of Radiation Oncology, Cliniques Universitaires Saint-Luc, Brussels, Belgium.
  • Enrique Alvarez Moreno
    Department of Radiation Oncology, Cliniques Universitaires Saint-Luc, Brussels, Belgium.
  • Andrea Colot
    Department of Radiation Oncology, Cliniques Universitaires Saint-Luc, Brussels, Belgium.
  • Simon Jardinet
    Department of Radiation Oncology, Cliniques Universitaires Saint-Luc, Brussels, Belgium.
  • Romain Mony
    Department of Radiation Oncology, Cliniques Universitaires Saint-Luc, Brussels, Belgium.
  • Ana Francisca Nevez Marques
    Department of Radiation Oncology, Cliniques Universitaires Saint-Luc, Brussels, Belgium.
  • Lola Servaes
    Department of Radiation Oncology, Cliniques Universitaires Saint-Luc, Brussels, Belgium.
  • Thaïs Tison
    Department of Radiation Oncology, Cliniques Universitaires Saint-Luc, Brussels, Belgium.
  • Valentin Van den Bossche
    Department of Radiation Oncology, Cliniques Universitaires Saint-Luc, Brussels, Belgium.
  • Aniko Wale Etume
    Department of Radiation Oncology, Cliniques Universitaires Saint-Luc, Brussels, Belgium.
  • Lamyae Zouheir
    Department of Radiation Oncology, Cliniques Universitaires Saint-Luc, Brussels, Belgium.
  • Geneviève Van Ooteghem
    Institut de Recherche Experimentale et Clinique (IREC), Center of Molecular Imaging, Radiotherapy and Oncology (MIRO), Université Catholique de Louvain, Brussels, Belgium.

Keywords

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