A pathway-informed disease-related gene identification approach and its application to screen novel risk genes for Alzheimer's disease.

Journal: Journal of Alzheimer's disease reports
Published Date: May 21, 2025

Abstract

BACKGROUND: Alzheimer's disease (AD) is a severe neurodegenerative disorder, yet its molecular mechanisms remain incompletely understood. It is known that the joint action of a number of genetic and other factors is involved in the pathogenesis of this disorder.

Authors

  • Xin Yuan
  • Lihui Gao
    School of Biomedical Engineering, Tianjin Medical University, Tianjin, China.
  • Hao Wang
    Department of Cardiology, Second Medical Center, Chinese PLA General Hospital, Beijing, China.
  • Ju Wang
    Insilico Medicine Hong Kong Ltd., Hong Kong Science and Technology Park, New Territories, Hong Kong, China.

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