Exploring the molecular mechanisms of huperzine a in the treatment of rosacea through network pharmacology, machine learning, and molecular dynamics simulations.

Journal: Frontiers in pharmacology
Published Date: May 22, 2025

Abstract

INTRODUCTION: Rosacea is a common chronic inflammatory skin disorder and dysregulation of neuroimmune functions and neurovascular loops play critical roles in the development of rosacea. Huperzine A (Hup A) has several bioactive properties, including anti-inflammatory, antioxidant, and neuroprotective effects. However, the potential roles of Hup A in treating rosacea is unknown.

Authors

  • Xin Luo
    Department of Pharmacology, The Basic Medical Sciences College of Xinjiang Medical University Urumqi 830054, China.
  • Suhan Yang
    Department of Dermatology, Second Xiangya Hospital, Hunan Key Laboratory of Medical Epigenomics, Clinical Medical Research Center of Major Skin Diseases and Skin Health of Hunan Province, Central South University, Changsha, Hunan, China.
  • Lian Zhong
    Department of Blood Transfusion, Pingxiang People's Hospital, Gannan Medical University, Pingxiang, China.
  • Peng Zhang
    Key Laboratory of Macromolecular Science of Shaanxi Province, School of Chemistry & Chemical Engineering, Shaanxi Normal University, Xi'an, Shaanxi 710062, China.

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