Identification of PRKCQ-AS1 as a Keratinocyte-Derived Exosomal lncRNA That Promotes Th17 Differentiation and IL-17 secretion in Psoriasis Through Bioinformatics, Machine Learning Algorithms, and Cell Experiments.

Journal: Journal of inflammation research
Published Date: May 22, 2025

Abstract

BACKGROUND: Psoriasis is an immune-mediated skin disease where Th17 cell differentiation and IL-17 secretion play critical roles. This study investigates key exosomal ncRNAs regulating the Th17/IL-17 axis in psoriasis and their mechanisms.

Authors

  • Pengfei Gao
    National Key Laboratory of Crop Genetic Improvement, College of Plant Science and Technology, Huazhong Agricultural University, No. 1 Shizishan Road, Hongshan District, Wuhan, Hubei 430070, China.
  • Xiaolu Gao
    Guangzhou University of Chinese Medicine, Guangzhou 510006, China.
  • Long Lin
    School of Economics and Management, Lanzhou University of Technology, Lanzhou, China.
  • Ming Zhang
    Heilongjiang Key Laboratory for Laboratory Animals and Comparative Medicine, College of Veterinary Medicine, Harbin 150030, China.
  • Dongqiang Luo
    The Second Clinical Medical College of Guangzhou University of Chinese Medicine, Guangzhou, China.
  • Chuyan Chen
    School of Yunkang Medicine and Health, Nanfang College, Guangzhou, People's Republic of China.
  • Yujie Li
    College of Orthopedics and Traumatology, Henan University of Chinese Medicine, Zhengzhou, China.
  • Yufeng He
    Guangdong Laboratory of Artificial Intelligence and Digital Economy (SZ), Shenzhen University, Guangdong Province, PR China.
  • Xianmiao Liu
    School of Yunkang Medicine and Health, Nanfang College, Guangzhou, People's Republic of China.
  • Chunyu Shi
    School of Yunkang Medicine and Health, Nanfang College, Guangzhou, People's Republic of China.
  • Ruisi Yang
    School of Yunkang Medicine and Health, Nanfang College, Guangzhou, People's Republic of China.

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