Proteomic analysis reveals modulation of key proteins in follicular thyroid cancer progression.

Journal: Chinese medical journal
Published Date:

Abstract

BACKGROUND: Cytopathology cannot be used to reliably distinguish follicular thyroid adenoma (FTA) from follicular thyroid carcinoma (FTC), the second most common form of thyroid cancer, because they exhibit nearly identical cellular morphology. Given the challenges in diagnosis and treatment, this study aims to identify the mechanisms underlying FTC is essential.

Authors

  • Xue Cai
    National and Local Joint Engineering Research Center for Biomanufacturing of Chiral Chemicals, Zhejiang University of Technology, Hangzhou, People's Republic of China.
  • Rui Sun
    The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325027, China.
  • Liang Yang
  • Nan Yao
    The Department of Radiology, Jiangmen Central Hospital/Affiliated Jiangmen Hospital of Sun Yat-Sen University, No. 23 Haibang Street, Jiangmen, 529000, Guangdong, China.
  • Yaoting Sun
    School of Medicine, School of Life Sciences, Westlake University, Hangzhou, China. sunyaoting@westlake.edu.cn.
  • Guangmei Zhang
    Affiliated Hangzhou First People's Hospital, State Key Laboratory of Medical Proteomics, School of Medicine, Westlake University, Hangzhou, Zhejiang 310024, China.
  • Weigang Ge
    Westlake Omics (Hangzhou) Biotechnology Co., Ltd., Hangzhou, Zhejiang, China.
  • Yan Zhou
    Department of Computer Science, University of Texas at Dallas, Richardson, Texas 75080, United States.
  • Zhiqiang Gui
    Department of Thyroid Surgery, The First Hospital of China Medical University, Shenyang 110001, China.
  • Yu Wang
    Clinical and Technical Support, Philips Healthcare, Shanghai, China.
  • Haitao Zheng
    Department of Thyroid Surgery, Yantai Yuhuangding Hospital, Qingdao University, Yantai, Shandong, 264000, People's Republic of China.
  • Dong Xu
    Department of Electrical Engineering and Computer Science, University of Missouri, Columbia, MO, USA.
  • Yongfu Zhao
    School of Computer, Qufu Normal University, 276826 Rizhao, People's Republic of China.
  • Xiu Nie
    Department of Pathology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, China.
  • Zhiyan Liu
    Department of Computer Science and Technology, Harbin Institute of Technology, Harbin, 150001, People's Republic of China.
  • Hao Zhang
    College of Mechanical and Electrical Engineering, Henan Agricultural University, Zhengzhou, 450002, China.
  • Pingping Hu
    Affiliated Hangzhou First People's Hospital, State Key Laboratory of Medical Proteomics, School of Medicine, Westlake University, Hangzhou, Zhejiang 310024, China.
  • Honghan Cheng
    Affiliated Hangzhou First People's Hospital, State Key Laboratory of Medical Proteomics, School of Medicine, Westlake University, Hangzhou, Zhejiang 310024, China.
  • Zhangzhi Xue
    Affiliated Hangzhou First People's Hospital, State Key Laboratory of Medical Proteomics, School of Medicine, Westlake University, Hangzhou, Zhejiang 310024, China.
  • Jiatong Wang
    Key Laboratory of Mechanism Theory and Equipment Design, Ministry of Education, Tianjin, China.
  • Jing Yu
    Department of Ultrasound, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
  • Chuang Chen
    College of Electrical Engineering and Control Science, Nanjing Tech University, Nanjing 211816, China.
  • Dingcun Luo
    Department of Oncological Surgery, Affiliated Hangzhou First People's Hospital, Westlake University School of Medicine, Hangzhou, 310006, Zhejiang, China. ldc65@163.com.
  • Jingqiang Zhu
    Department of Thyroid Surgery, West China Hospital, Sichuan University, Chengdu, China.
  • Tong Liu
    Intensive Care Medical Center, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200065, People's Republic of China.
  • Yifeng Zhang
    Department of Environmental & Resource Engineering, Technical University of Denmark, Kongens Lyngby DK-2800, Denmark.
  • Qijun Wu
    Department of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, China.
  • Qiaonan Guo
    Department of Breast and Thyroid Surgery, Second Affiliated Hospital of Fujian Medical University, Quanzhou, China.
  • Wanyuan Chen
  • Jianbiao Wang
    Clinical Laboratory, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
  • Wenjun Wei
    a State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering , Lanzhou University , Lanzhou , People's Republic of China.
  • Xiangfeng Lin
    Department of Thyroid Surgery, The Affiliated Yantai Yuhuangding Hospital, Qingdao University, Qingdao, Shandong Province, China.
  • Jincao Yao
    Department of Diagnostic Ultrasound Imaging & Interventional Therapy, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, China.
  • Guangzhi Wang
    Department of Biomedical Engineering, School of Medicine, Tsinghua University, Room C249, Beijing, 100084, China. Electronic address: wgz-dea@tsinghua.edu.cn.
  • Li Peng
    School of Internet of Things Engineering, Jiangnan University, Wuxi 214122, China. pengli@jiangnan.edu.cn.
  • Shuyi Liu
    The Experimental High School Attached to Beijing Normal University, No. 14 Erlong Road, Beijing 100051, PR China.
  • Zhihong Wang
    Department of Endocrinology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
  • Hanqing Liu
    Biotechnology Research Institute, Chinese Academy of Agricultural Sciences, Beijing, 100081, China.
  • Jiaxi Wang
    Key Laboratory of Optoelectronic Technology and System of the Education Ministry of China, Chongqing University, Chongqing 400044, People's Republic of China. Engineering Research Center of Industrial Computed Tomography Nondestructive Testing of the Education Ministry of China, Chongqing University, Chongqing 400044, People's Republic of China.
  • Fan Wu
    Department of Product Design, Dalian Polytechnic University, Dalian 116034, China.
  • Zhennan Yuan
    Department of Oncology Surgery, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang 150081, China.
  • Tingting Gong
    Department of Gastroenterology, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
  • Yangfan Lv
    Department of Pathology, Xinqiao Hospital, Third Military Medical University (Army Medical University), Chongqing 400037, China.
  • Jingjing Xiang
    Department of Pharmacy, Affiliated Nantong Hospital of Shanghai University (The Sixth People's Hospital of Nantong), Nantong, China.
  • Yi Zhu
    2State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, Guangdong China.
  • Lei Xie
    Ph.D. Program in Computer Science, The City University of New York, New York, NY, United States.
  • Minghua Ge
    Otolaryngology and Head and Neck Center, Cancer Center, Department of Head and Neck Surgery, Zhejiang Provincial People's Hospital (Affiliated People's Hospital, Hangzhou Medical College), Hangzhou, Zhejiang 310006, China.
  • Haixia Guan
    Department of Endocrinology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, Guangdong 510080, China.
  • Tiannan Guo
    Institute of Basic Medical Sciences, School of Life Science, Westlake University, Hangzhou 310024, China.

Keywords

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