Immune-related gene risk model establishment and role of key gene FUCA1 in malignant pleural mesothelioma.

Journal: Frontiers in pharmacology
Published Date: May 23, 2025

Abstract

BACKGROUND: Malignant pleural mesothelioma (MPM) is a rare type of tumor closely associated with asbestos exposure. Increasing evidence shows that high immuno-heterogeneity reduces the therapeutic efficacy of MPM. At present, good biomarkers to screen immunodominant populations and predict the efficacy of immunotherapy are lacking.

Authors

  • Lin Shi
    Department of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Shatin, China.
  • Dongqi Yuan
    Department of Tumor Cell Biology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.
  • Fuyi Zhu
    Beijing Children's Hospital, Capital Medical University, Beijing, China.
  • Yuchao He
    Department of Tumor Cell Biology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.
  • Ran Zuo
    National Clinical Research Center for Cancer, State Key Laboratory of Druggability Evaluation and Systematic Translational Medicine, Tianjin's Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China.
  • Liwei Chen
    Department of Automation, School of Electrical Engineering, Zhengzhou University, Zhengzhou 450001, China.
  • Yi Luo
    Electrical and Computer Engineering Department, Bioengineering Department, University of California, Los Angeles, CA 90095 USA, and also with the California NanoSystems Institute, University of California, Los Angeles, CA 90095 USA.
  • Yu Wang
    Clinical and Technical Support, Philips Healthcare, Shanghai, China.
  • Dingzhi Huang
    Department of Thoracic Oncology, Lung Cancer Diagnosis and Treatment Center, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.
  • Peng Chen
  • Hua Guo
    Zhumadian Psychiatric Hospital, Zhumadian 463000, Henan, China.

Keywords

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