FLAMeS: A Robust Deep Learning Model for Automated Multiple Sclerosis Lesion Segmentation.

Journal: medRxiv : the preprint server for health sciences
Published Date:

Abstract

BACKGROUND AND PURPOSE: Assessment of brain lesions on MRI is crucial for research in multiple sclerosis (MS). Manual segmentation is time consuming and inconsistent. We aimed to develop an automated MS lesion segmentation algorithm for T2-weighted fluid-attenuated inversion recovery (FLAIR) MRI.

Authors

  • Emma Dereskewicz
    Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
  • Francesco La Rosa
    Signal Processing Laboratory (LTS5), École Polytechnique Fédérale de Lausanne, Switzerland; Medical Image Analysis Laboratory, Center for Biomedical Imaging (CIBM), University of Lausanne, Switzerland; Department of Radiology, Lausanne University Hospital and University of Lausanne, Switzerland. Electronic address: francesco.larosa@epfl.ch.
  • Jonadab Dos Santos Silva
    Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
  • Edward Sizer
    Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
  • Amit Kohli
    Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
  • Maxence Wynen
    ICTeam, Université Catholique de Louvain, Louvain-la-Neuve, Belgium.
  • William A Mullins
    Translational Neuroradiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
  • Pietro Maggi
    Department of Neurology, Lausanne University Hospital, Lausanne, Switzerland.
  • Sarah Levy
    S.D. Sight Diagnostics LTD, Tel Aviv-Jaffa, Israel.
  • Kamso Onyemeh
    Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
  • Batuhan Ayci
    Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
  • Andrew J Solomon
  • Jakob Assländer
    Center for Biomedical Imaging, Department of Radiology, New York University School of Medicine, New York City, New York, USA.
  • Omar Al-Louzi
    Translational Neuroradiology Section, National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA; Neuroimmunology Clinic, National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA.
  • Daniel S Reich
  • James Sumowski
    Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
  • Erin S Beck
    Translational Neuroradiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD.

Keywords

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