Host Biomarkers and Antibiotic Tissue Penetration in Sepsis: Insights from Moxifloxacin.

Journal: European journal of drug metabolism and pharmacokinetics
Published Date: Apr 23, 2025

Abstract

BACKGROUND AND OBJECTIVE: Sepsis-induced pathophysiological changes may lead to pharmacokinetic variability which alters antibiotic concentrations at the host infection site. This poses a challenge in clinical practice, as sufficient antibiotic concentrations in tissue are necessary to effectively eradicate bacterial pathogens. In this exploratory study, we aimed to evaluate the potential of routinely used laboratory biomarkers to predict subcutaneous and muscle tissue penetration of moxifloxacin in septic patients.

Authors

  • Maria Sanz-Codina
    Department of Clinical Pharmacology, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.
  • Hartmuth Nowak
    Department of Anaesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Knappschaftskrankenhaus, Bochum, Ruhr-University Bochum, In der Schornau 23-25, 44892, Bochum, Germany.
  • Markus Zeitlinger
    Department of Clinical Pharmacology, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria. markus.zeitlinger@meduniwien.ac.at.

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