Investigating the Mechanisms of Pazopanib-induced Hepatotoxicity: Insights from Network Toxicology, Microarray Analysis, and Machine Learning.

Journal: Current medicinal chemistry
Published Date: May 23, 2025

Abstract

BACKGROUND: Pazopanib is an oral multi-kinase inhibitor that is effective in treating various tumors. However, it is commonly associated with hepatotoxicity, which can interrupt treatments and cause delays, thereby increasing the risk of tumor progression. The mechanisms underlying pazopanib-induced hepatotoxicity remain unclear and limit the development of effective preventive strategies. This study aimed to identify the core gene products and investigate the mechanisms associated with pazopanib-induced hepatotoxicity by integrating network toxicology, microarray analysis, and machinelearning.

Authors

  • Yidong Zhu
    Department of Traditional Chinese Medicine, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, 200072, China.
  • Jun Liu
    Department of Radiology, Second Xiangya Hospital, Changsha, Hunan, China.
  • Fei Wang
    Department of Population Health Sciences, Weill Cornell Medicine, Cornell University, New York, NY, United States.

Keywords

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