Automated detection of severe cerebral edema using explainable deep transfer learning after hypoxic ischemic brain injury.

Journal: Resuscitation
Published Date: May 23, 2025

Abstract

BACKGROUND: Substantial gaps exist in the neuroprognostication of cardiac arrest patients who remain comatose after the restoration of spontaneous circulation. Most studies focus on predicting survival, a measure confounded by the withdrawal of life-sustaining treatment decisions. Severe cerebral edema (SCE) may serve as an objective proximal imaging-based surrogate of neurologic injury.

Authors

  • Zihao Wang
    Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China.
  • Annelise M Kulpanowski
    Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA.
  • William A Copen
    Department of Radiology, Neuroradiology Division, Massachusetts General Hospital, Boston, MA 02114, USA.
  • Eric S Rosenthal
    Department of Neurology, Massachusetts General Hospital, Boston, MA.
  • Jacob A Dodelson
    Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA.
  • David E McCrory
    Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA.
  • Brian L Edlow
    Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, USA; Center for Neurotechnology and Neurorecovery, Massachusetts General Hospital, Boston, USA.
  • W Taylor Kimberly
    Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA.
  • Edilberto Amorim
    Department of Neurology, Massachusetts General Hospital, Boston, MA, USA; Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA, USA. Electronic address: edilbertoamorim@gmail.com.
  • M Brandon Westover
    Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA; Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.
  • MingMing Ning
    Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA.
  • Morteza Zabihi
    Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
  • Pamela W Schaefer
    Department of Radiology, Division of Neuroradiology, Massachusetts General Hospital, Harvard Medical School, Room: GRB-273A, 55 Fruit Street, Boston, MA 02114, USA.
  • Rajeev Malhotra
    Department of Medicine, Cardiology Division, Massachusetts General Hospital, Boston, MA 02114, USA.
  • Joseph T Giacino
    Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital, Charlestown, MA 02129, USA.
  • David M Greer
    Boston University School of Medicine, Boston, Massachusetts, United States of America.
  • Ona Wu

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