Prognostic model identification of ribosome biogenesis-related genes in pancreatic cancer based on multiple machine learning analyses.

Journal: Discover oncology
Published Date: May 24, 2025

Abstract

BACKGROUND: Pancreatic cancer is a highly aggressive cancer characterized by low survival rate. Enhanced ribosome biogenesis may be associated with tumor drug resistance and malignant phenotypes, representing a potential therapeutic target in pancreatic cancer. Therefore, exploring the molecular mechanisms of ribosome biogenesis in pancreatic cancer may uncover new biomarkers and potential therapeutic targets, facilitating the development of personalized treatment strategies.

Authors

  • Yuan Sun
    Pharmacy Department of Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
  • Yan Li
    Interdisciplinary Research Center for Biology and Chemistry, Liaoning Normal University, Dalian, China.
  • Anlan Zhang
    Department of Hepatobiliary Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
  • Tao Hu
    Department of Preventive Dentistry, State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.
  • Ming Li
    Radiology Department, Huadong Hospital, Affiliated with Fudan University, Shanghai, China.

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