Unraveling the significance of cuproptosis in hepatocellular carcinoma heterogeneity and tumor microenvironment through integrated single-cell sequencing and machine learning approaches.

Journal: Discover oncology
Published Date: May 24, 2025

Abstract

BACKGROUND: Hepatocellular carcinoma (HCC) exhibits pronounced heterogeneity, which significantly limits the effectiveness of precision therapies. A comprehensive understanding of the biological characteristics and molecular mechanisms underlying HCC cell subpopulations is crucial for improving prognostic predictions and refining treatment strategies.

Authors

  • Wang Liu
    Department of General Surgery, Sanya Central Hospital (The Third People's Hospital of Hainan Province), Sanya, China.
  • Liangjing Xia
    College of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China.
  • Yuan Peng
    Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
  • Qiang Cao
    Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
  • Ke Xu
    Mechatronics Engineering of University of Electronic Science and Technology of China, Chengdu, 611731, China.
  • Huiyan Luo
    Department of Medical Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China.
  • Yongjun Peng
    Department of Orthopedics, Xichong People's Hospital, Nanchong, 637200, China. 18382971713@163.com.
  • Yanping Zhang
    Key Laboratory of Intelligent Computing and Signal Processing of Ministry of Education, ‡School of Computer Science and Technology, and §Center of Information Support & Assurance Technology, Anhui University , Hefei, 230601 Anhui, China.

Keywords

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