Evaluation of locoregional invasiveness of early lung adenocarcinoma manifesting as ground-glass nodules via [Ga]Ga-FAPI-46 PET/CT imaging.

Journal: European journal of nuclear medicine and molecular imaging
Published Date: May 24, 2025

Abstract

PURPOSE: Accurate differentiation of the histologic invasiveness of early-stage lung adenocarcinoma is crucial for determining surgical strategies. This study aimed to investigate the potential of [Ga]Ga-FAPI-46 PET/CT in assessing the invasiveness of early lung adenocarcinoma presenting as ground-glass nodules (GGNs) and identifying imaging features with strong predictive potential.

Authors

  • Dan Ruan
    Departments of Radiation Oncology, Biomedical Physics and Bioengineering, UCLA, Los Angeles, CA, 90095, USA.
  • Sien Shi
    Department of Thoracic Surgery, The First Affiliated Hospital of Xiamen University, Xiamen, China.
  • Weixi Guo
    Department of Thoracic Surgery, The First Affiliated Hospital of Xiamen University, Xiamen, China.
  • Yizhen Pang
    Department of Nuclear Medicine and Minnan PET Center, Xiamen Key Laboratory of Radiopharmaceuticals, School of Medicine, The First Affiliated Hospital of Xiamen University, Xiamen University, Xiamen, China.
  • Lingyu Yu
    Department of Mechanical Engineering, University of South Carolina, Columbia, SC 29208, USA.
  • Jiayu Cai
    Department of Nuclear Medicine and Minnan PET Center, Xiamen Key Laboratory of Radiopharmaceuticals, School of Medicine, The First Affiliated Hospital of Xiamen University, Xiamen University, Xiamen, China.
  • Zhenyu Wu
    Department of Biomedical Informatics, The Ohio State University, Columbus, OH 43210, USA.
  • Hua Wu
    Research and Development Center of Biorational Pesticide, Northwest Agriculture & Forestry University, Yangling, Shaanxi 712100, PR China. Electronic address: huawu686@aliyun.com.
  • Long Sun
    Department of Urology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, 310000, China.
  • Liang Zhao
    Graduate School of Advanced Integrated Studies in Human Survivability (Shishu-Kan), Kyoto University, Kyoto, Japan.
  • Haojun Chen
    Department of Nuclear Medicine and Minnan PET Center, Xiamen Key Laboratory of Radiopharmaceuticals, School of Medicine, The First Affiliated Hospital of Xiamen University, Xiamen University, Xiamen, China. leochen0821@foxmail.com.

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