Multidimensional Evidence Chain of Nutritional Impact on Digestive System Tumors: Integration of Mendelian Randomization Causal Inference, NHANES Epidemiological Data, and Transcriptomic Analysis.

Journal: Nutrition and cancer
Published Date: May 25, 2025

Abstract

BACKGROUND: The global burden of digestive system tumors (e.g., hepatocellular carcinoma, gastric cancer, colorectal cancer) continues to rise, with low survival rates in advanced stages, necessitating etiology-based intervention strategies. Nutritional metabolic disorders are closely linked to tumor progression, but existing studies predominantly focus on correlational analyses, leaving causal relationships and molecular mechanisms poorly understood.

Authors

  • Yuan Chen
    Department of Biostatistics, Mailman School of Public Health, Columbia University, New York, NY 10032.
  • Yaodong Ping
    Department of Pharmacy, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital & Institute, Beijing, China.
  • Hong Liu
    Key Laboratory of Grain and Oil Processing and Food Safety of Sichuan Province, College of Food and Bioengineering, Xihua University Chengdu 610039 China xingyage1@163.com.
  • Benben Zhu
    Department of Pharmacy, Peking University Cancer Hospital (Inner Mongolia Campus)/Affiliated Cancer Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia Autonomous Region, China.
  • Xueyan Jiang
    Department of Pharmacy, Peking University Cancer Hospital (Inner Mongolia Campus)/Affiliated Cancer Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia Autonomous Region, China.
  • Rong Fu
    School of Biomedical Engineering, Southern Medical University, Guangzhou 510515, China.
  • Yiwei Hao
    Division of Medical Record and Statistics, Beijing Ditan Hospital, Capital Medical University, Beijing, China.
  • Yan Yang
    Department of Endocrinology and Metabolism, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
  • Chunlei Miao
    Inner Mongolia Medical University, Hohhot, Inner Mongolia Autonomous Region, China.
  • Yuli Liu
    Department of Pharmacy, Peking University Cancer Hospital (Inner Mongolia Campus)/Affiliated Cancer Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia Autonomous Region, China.

Keywords

No keywords available for this article.

External Resources

Popular Topics
Recent Journals