Integrating a host transcriptomic biomarker with a large language model for diagnosis of lower respiratory tract infection.

Journal: medRxiv : the preprint server for health sciences
Published Date: Apr 3, 2025

Abstract

BACKGROUND: Lower respiratory tract infections (LRTIs) are a leading cause of mortality worldwide and can be difficult to diagnose in critically ill patients, as non-infectious causes of respiratory failure can present with similar clinical features.

Authors

  • Hoang Van Phan
    Department of Medicine, Division of Infectious Diseases, University of California San Francisco.
  • Natasha Spottiswoode
    Department of Medicine, Division of Infectious Diseases, University of California San Francisco.
  • Emily C Lydon
    Department of Medicine, Division of Infectious Diseases, University of California San Francisco.
  • Victoria T Chu
    Department of Pediatrics, Division of Infectious Diseases and Global Health, University of California San Francisco.
  • Adolfo Cuesta
    Department of Medicine, Division of Infectious Diseases, University of California San Francisco.
  • Alexander D Kazberouk
    Department of Medicine, University of California San Francisco.
  • Natalie L Richmond
    Department of Medicine, Division of Infectious Diseases, University of California San Francisco.
  • Padmini Deosthale
    Department of Medicine, Division of Infectious Diseases, University of California San Francisco.
  • Carolyn S Calfee
    Department of Medicine, Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, University of California San Francisco.
  • Charles R Langelier
    Department of Medicine, Division of Infectious Diseases, University of California San Francisco.

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