Identification of autophagy-related genes in intestinal ischemia-reperfusion injury and their role in immune infiltration.

Journal: Frontiers in physiology
Published Date: May 26, 2025

Abstract

BACKGROUND: Intestinal ischemia-reperfusion (II/R) injury is a serious condition characterized by high morbidity and mortality rates. Research has shown that II/R injury is closely linked to autophagy and immune dysregulation. This study aims to investigate the potential correlations between autophagy-related genes and infiltrating immune cells in II/R injury.

Authors

  • Yichen Hu
    Key Laboratory of Coarse Cereal Processing, Ministry of Agriculture and Rural Affairs, School of Pharmacy, Key Laboratory of Medicinal and Edible Plants Resources Development of Sichuan Education Department, Sichuan Industrial Institute of Antibiotics, Chengdu University, Chengdu 610106, China.
  • Qinghua Zou
    Department of Gastrointestinal Surgery, Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
  • Yanbo Sun
    Department of Gastrointestinal Surgery, Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
  • Weiming Li
    Shanghai Nuanhe Brain Technology Co., Ltd, Shanghai, China.
  • Zhaochuan Yin
    Department of Gastrointestinal Surgery, Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
  • Yuanpei Zhao
    Department of Gastrointestinal Surgery, Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
  • Kaiwen Shi
    Department of Gastrointestinal Surgery, Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
  • Hongyuan Liu
    Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Jiahui Wang
    School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, China.

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